Bone Mineral Density across the Lifespan in Patients with Type 1 Diabetes

Eitan Halper-Stromberg, Tyler Gallo, Anagha Champakanath, Iman Taki, Marian Rewers, Janet Snell-Bergeon, Brigitte I. Frohnert, Viral N. Shah

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Context: Fracture risk in people with type 1 diabetes (T1D) is higher than their peers without diabetes. Objective: To compare bone mineral density (BMD) across the lifespan in individuals with T1D and age-and sex-matched healthy controls. Design: Cross-sectional. Setting: Subjects (5-71 years) with T1D and matched controls from ongoing research studies at Barbara Davis Center for Diabetes. Patients or other participants: Participants with lumbar spine BMD by dual X-ray absorptiometry (DXA) were divided into 2 groups: children ≤20 years and adults >20 years. Intervention: None. Main outcome measures: Comparison of BMD by diabetes status across age groups and sex using a linear least squares model adjusted for age and body mass index (body mass index (BMI) for adults; and BMI z-score in children). Results: Lumbar spine BMD from 194 patients with T1D and 156 controls were analyzed. There was no difference in age-and BMI-adjusted lumbar spine BMD between patients with T1D and controls: among male children (least squares mean ± standard error of the mean [LSM ± SEM]; 0.80 ± 0.01 vs 0.80 ± 0.02 g/cm2, P =. 98) or adults (1.01 ± 0.03 vs 1.01 ± 0.03 g/cm2, P =. 95), and female children (0.78 ± 0.02 vs 0.81 ± 0.02 g/cm2, P =. 23) or adults (0.98 ± 0.02 vs 1.01 ± 0.02 g/cm2, P =. 19). Lumbar spine (0.98 ± 0.02 vs 1.04 ± 0.02 g/cm2, P =. 05), femoral neck (0.71 ± 0.02 vs 0.79 ± 0.02 g/cm2, P =. 003), and total hip (0.84 ± 0.02 vs 0.91 ± 0.02, P =. 005) BMD was lower among postmenopausal women with T1D than postmenopausal women without diabetes. Conclusion: Across age groups, lumbar spine BMD was similar in patients with T1D compared with age-and sex-matched participants without diabetes, except postmenopausal females with T1D had lower lumbar spine, femoral neck, and total hip BMD.

Original languageEnglish (US)
Article numberdgz153
JournalJournal of Clinical Endocrinology and Metabolism
Issue number3
StatePublished - Jan 8 2020
Externally publishedYes


  • bone accrual
  • bone health
  • bone mineral density
  • dual X-ray absorptiometry
  • life-span
  • type 1 diabetes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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