Bone cancer pain

Juan Miguel Jimenez-Andrade, William G. Mantyh, Aaron P. Bloom, Alice S. Ferng, Christopher P. Geffre, Patrick W. Mantyh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

207 Scopus citations


In the United States, cancer is the second most common cause of death and it is expected that about 562,340 Americans will have died of cancer in 2009. Bone cancer pain is common in patients with advanced breast, prostate, and lung cancer as these tumors have a remarkable affinity to metastasize to bone. Once tumors metastasize to bone, they are a major cause of morbidity and mortality as the tumor induces significant skeletal remodeling, fractures, pain, and anemia. Currently, the factors that drive cancer pain are poorly understood. However, several recently introduced models of bone cancer pain, which closely mirror the human condition, are providing insight into the mechanisms that drive bone cancer pain and guide the development of mechanism-based therapies to treat the cancer pain. Several of these mechanism-based therapies have now entered human clinical trials. If successful, these therapies have the potential to significantly enlarge the repertoire of modalities that can be used to treat bone cancer pain and improve the quality of life, functional status, and survival of patients with bone cancer.

Original languageEnglish (US)
Title of host publicationNeurons and Networks in the Spinal Cord
PublisherBlackwell Publishing Inc.
Number of pages9
ISBN (Print)9781573317788
StatePublished - Jun 2010

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


  • osteosarcoma
  • prostate
  • therapies

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • History and Philosophy of Science


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