TY - JOUR
T1 - Body pain and treatment response in late-life depression
AU - Karp, Jordan F.
AU - Weiner, Debra
AU - Seligman, Karen
AU - Butters, Meryl
AU - Miller, Mark
AU - Frank, Ellen
AU - Stack, Jacqueline
AU - Mulsant, Benoit H.
AU - Pollock, Bruce
AU - Dew, Mary Amanda
AU - Kupfer, David J.
AU - Reynolds, Charles F.
N1 - Funding Information:
This work was supported in part by NIMH grants R37 MH43832, P30 MH52247, RR-00056, T32-MH19986, and R01 MH37869 .
PY - 2005/3
Y1 - 2005/3
N2 - Objective: The authors investigated the influence of body pain on 1) time to treatment response and 2) suicidal ideation, in late-life depression. They hypothesized that higher levels of body pain would predict a longer time to and lower likelihood of response, and increased levels of suicidal ideation. Methods: Subjects (N = 187) were older adult outpatients (age ≥ 69 years), with current episodes of major depression, who were openly treated with paroxetine up to 40 mg daily and weekly interpersonal psychotherapy. Response was defined as 3 consecutive weeks of Hamilton Rating Scale for Depression at < 10. Body pain was measured with the Bodily Pain Index of the SF-36 quality-of-life assessment. Authors used survival-analysis models on the responder sample to test the effect of body pain on response, after controlling for severity of depression. Results: Overall response rate was 75.4%. Nonresponders reported more severe pain at baseline. After covarying for severity of baseline depression, no effect was found for physical pain on time-to-response or degree of suicidality. Bodily pain remained stable during acute treatment for responders, independent of depression response to combination psychotherapy and antidepressant treatment. Conclusions: Older adult patients with higher levels of physical pain can still respond to antidepressant treatment; however, reported bodily pain may be associated with a more difflcult-to-treat depression.
AB - Objective: The authors investigated the influence of body pain on 1) time to treatment response and 2) suicidal ideation, in late-life depression. They hypothesized that higher levels of body pain would predict a longer time to and lower likelihood of response, and increased levels of suicidal ideation. Methods: Subjects (N = 187) were older adult outpatients (age ≥ 69 years), with current episodes of major depression, who were openly treated with paroxetine up to 40 mg daily and weekly interpersonal psychotherapy. Response was defined as 3 consecutive weeks of Hamilton Rating Scale for Depression at < 10. Body pain was measured with the Bodily Pain Index of the SF-36 quality-of-life assessment. Authors used survival-analysis models on the responder sample to test the effect of body pain on response, after controlling for severity of depression. Results: Overall response rate was 75.4%. Nonresponders reported more severe pain at baseline. After covarying for severity of baseline depression, no effect was found for physical pain on time-to-response or degree of suicidality. Bodily pain remained stable during acute treatment for responders, independent of depression response to combination psychotherapy and antidepressant treatment. Conclusions: Older adult patients with higher levels of physical pain can still respond to antidepressant treatment; however, reported bodily pain may be associated with a more difflcult-to-treat depression.
UR - http://www.scopus.com/inward/record.url?scp=22744448460&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=22744448460&partnerID=8YFLogxK
U2 - 10.1097/00019442-200503000-00003
DO - 10.1097/00019442-200503000-00003
M3 - Article
AN - SCOPUS:22744448460
SN - 1064-7481
VL - 13
SP - 188
EP - 194
JO - American Journal of Geriatric Psychiatry
JF - American Journal of Geriatric Psychiatry
IS - 3
ER -