TY - JOUR
T1 - Body mass predicts orbitofrontal activity during visual presentations of high-calorie foods
AU - Killgore, William D.S.
AU - Yurgelun-Todd, Deborah A.
PY - 2005/5/31
Y1 - 2005/5/31
N2 - Little is known about the relationship between weight status and reward-related brain activity in normal weight humans. We correlated orbitofrontal and anterior cingulate cortex activity as measured by functional magnetic resonance imaging with body mass index in 13 healthy, normal-weight adult women as they viewed images of high-calorie and low-calorie foods, and dining-related utensils. Body mass index correlated negatively with both cingulate and orbitofrontal activity during high-calorie viewing, negatively with orbitofrontal activity during low-calorie viewing, and positively with orbitofrontal activity during presentations of nonedible utensils. With greater body mass, activity was reduced in brain regions important for evaluating and modifying learned stimulus-reward associations, suggesting a relationship between weight status and responsiveness of the orbitofrontal cortex to rewarding food images.
AB - Little is known about the relationship between weight status and reward-related brain activity in normal weight humans. We correlated orbitofrontal and anterior cingulate cortex activity as measured by functional magnetic resonance imaging with body mass index in 13 healthy, normal-weight adult women as they viewed images of high-calorie and low-calorie foods, and dining-related utensils. Body mass index correlated negatively with both cingulate and orbitofrontal activity during high-calorie viewing, negatively with orbitofrontal activity during low-calorie viewing, and positively with orbitofrontal activity during presentations of nonedible utensils. With greater body mass, activity was reduced in brain regions important for evaluating and modifying learned stimulus-reward associations, suggesting a relationship between weight status and responsiveness of the orbitofrontal cortex to rewarding food images.
KW - Anterior cingulate gyrus
KW - Body mass index
KW - Calorie
KW - Eating
KW - Food
KW - Functional magnetic resonance imaging
KW - Limbic system
KW - Neuroimaging
KW - Orbitofrontal cortex
UR - http://www.scopus.com/inward/record.url?scp=19544381369&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=19544381369&partnerID=8YFLogxK
U2 - 10.1097/00001756-200505310-00016
DO - 10.1097/00001756-200505310-00016
M3 - Article
C2 - 15891585
AN - SCOPUS:19544381369
VL - 16
SP - 859
EP - 863
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 8
ER -