Abstract
Little is known about the relationship between weight status and reward-related brain activity in normal weight humans. We correlated orbitofrontal and anterior cingulate cortex activity as measured by functional magnetic resonance imaging with body mass index in 13 healthy, normal-weight adult women as they viewed images of high-calorie and low-calorie foods, and dining-related utensils. Body mass index correlated negatively with both cingulate and orbitofrontal activity during high-calorie viewing, negatively with orbitofrontal activity during low-calorie viewing, and positively with orbitofrontal activity during presentations of nonedible utensils. With greater body mass, activity was reduced in brain regions important for evaluating and modifying learned stimulus-reward associations, suggesting a relationship between weight status and responsiveness of the orbitofrontal cortex to rewarding food images.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 859-863 |
| Number of pages | 5 |
| Journal | NeuroReport |
| Volume | 16 |
| Issue number | 8 |
| DOIs | |
| State | Published - May 31 2005 |
| Externally published | Yes |
Keywords
- Anterior cingulate gyrus
- Body mass index
- Calorie
- Eating
- Food
- Functional magnetic resonance imaging
- Limbic system
- Neuroimaging
- Orbitofrontal cortex
ASJC Scopus subject areas
- General Neuroscience