Blood pressure variability and plasma Alzheimer’s disease biomarkers in older adults

Isabel J. Sible; Belinda Yew; Jung Yun Jang; John Paul M. Alitin; Yanrong Li; Aimée Gaubert; Amy Nguyen; Shubir Dutt; Anna E. Blanken; Jean K. Ho; Anisa J. Marshall; Arunima Kapoor; Fatemah Shenasa; Kathleen E. Rodgers; Virginia E. Sturm; Elizabeth Head; Alessandra Martini; Daniel A. Nation

doi:10.1038/s41598-022-20627-4

Blood pressure variability and plasma Alzheimer’s disease biomarkers in older adults

Isabel J. Sible, Belinda Yew, Jung Yun Jang, John Paul M. Alitin, Yanrong Li, Aimée Gaubert, Amy Nguyen, Shubir Dutt, Anna E. Blanken, Jean K. Ho, Anisa J. Marshall, Arunima Kapoor, Fatemah Shenasa, Kathleen E. Rodgers, Virginia E. Sturm, Elizabeth Head, Alessandra Martini, Daniel A. Nation

Pharmacology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Blood pressure variability is an emerging risk factor for Alzheimer’s disease in older adults, independent of average blood pressure levels. Growing evidence suggests increased blood pressure variability is linked to Alzheimer’s disease pathophysiology indexed by cerebrospinal fluid and positron emission tomography markers, but relationships with plasma Alzheimer’s disease markers have not been investigated. In this cross-sectional study of 54 community-dwelling older adults (aged 55–88, mean age 69.9 [8.2 SD]), elevated blood pressure variability over 5 min was associated with lower levels of plasma Aβ_1–42 (standardized ß = − 0.36 [95% CI − 0.61, − 0.12]; p = 0.005; adjusted R² = 0.28) and Aβ_1–42: Aβ_1–40 ratio (ß = − 0.49 [95% CI − 0.71, − 0.22]; p < 0.001; adjusted R² = 0.28), and higher levels of total tau (ß = 0.27 [95% CI 0.01, 0.54]; p = 0.04; adjusted R² = 0.19) and Ptau₁₈₁:Aβ_1–42 ratio (ß = 0.26 [95% CI 0.02, 0.51]; p = 0.04; adjusted R² = 0.22). Findings suggest higher blood pressure variability is linked to plasma biomarkers of increased Alzheimer’s disease pathophysiology.

Original language	English (US)
Article number	17197
Journal	Scientific reports
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41598-022-20627-4
State	Published - Dec 2022

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Sible, I. J., Yew, B., Jang, J. Y., Alitin, J. P. M., Li, Y., Gaubert, A., Nguyen, A., Dutt, S., Blanken, A. E., Ho, J. K., Marshall, A. J., Kapoor, A., Shenasa, F., Rodgers, K. E., Sturm, V. E., Head, E., Martini, A., & Nation, D. A. (2022). Blood pressure variability and plasma Alzheimer’s disease biomarkers in older adults. Scientific reports, 12(1), Article 17197. https://doi.org/10.1038/s41598-022-20627-4

Sible, IJ, Yew, B, Jang, JY, Alitin, JPM, Li, Y, Gaubert, A, Nguyen, A, Dutt, S, Blanken, AE, Ho, JK, Marshall, AJ, Kapoor, A, Shenasa, F, Rodgers, KE, Sturm, VE, Head, E, Martini, A & Nation, DA 2022, 'Blood pressure variability and plasma Alzheimer’s disease biomarkers in older adults', Scientific reports, vol. 12, no. 1, 17197. https://doi.org/10.1038/s41598-022-20627-4

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title = "Blood pressure variability and plasma Alzheimer{\textquoteright}s disease biomarkers in older adults",

abstract = "Blood pressure variability is an emerging risk factor for Alzheimer{\textquoteright}s disease in older adults, independent of average blood pressure levels. Growing evidence suggests increased blood pressure variability is linked to Alzheimer{\textquoteright}s disease pathophysiology indexed by cerebrospinal fluid and positron emission tomography markers, but relationships with plasma Alzheimer{\textquoteright}s disease markers have not been investigated. In this cross-sectional study of 54 community-dwelling older adults (aged 55–88, mean age 69.9 [8.2 SD]), elevated blood pressure variability over 5 min was associated with lower levels of plasma Aβ1–42 (standardized {\ss} = − 0.36 [95% CI − 0.61, − 0.12]; p = 0.005; adjusted R2 = 0.28) and Aβ1–42: Aβ1–40 ratio ({\ss} = − 0.49 [95% CI − 0.71, − 0.22]; p < 0.001; adjusted R2 = 0.28), and higher levels of total tau ({\ss} = 0.27 [95% CI 0.01, 0.54]; p = 0.04; adjusted R2 = 0.19) and Ptau181:Aβ1–42 ratio ({\ss} = 0.26 [95% CI 0.02, 0.51]; p = 0.04; adjusted R2 = 0.22). Findings suggest higher blood pressure variability is linked to plasma biomarkers of increased Alzheimer{\textquoteright}s disease pathophysiology.",

author = "Sible, {Isabel J.} and Belinda Yew and Jang, {Jung Yun} and Alitin, {John Paul M.} and Yanrong Li and Aim{\'e}e Gaubert and Amy Nguyen and Shubir Dutt and Blanken, {Anna E.} and Ho, {Jean K.} and Marshall, {Anisa J.} and Arunima Kapoor and Fatemah Shenasa and Rodgers, {Kathleen E.} and Sturm, {Virginia E.} and Elizabeth Head and Alessandra Martini and Nation, {Daniel A.}",

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year = "2022",

month = dec,

doi = "10.1038/s41598-022-20627-4",

language = "English (US)",

volume = "12",

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AU - Sible, Isabel J.

AU - Yew, Belinda

AU - Jang, Jung Yun

AU - Alitin, John Paul M.

AU - Li, Yanrong

AU - Gaubert, Aimée

AU - Nguyen, Amy

AU - Dutt, Shubir

AU - Blanken, Anna E.

AU - Ho, Jean K.

AU - Marshall, Anisa J.

AU - Kapoor, Arunima

AU - Shenasa, Fatemah

AU - Rodgers, Kathleen E.

AU - Sturm, Virginia E.

AU - Head, Elizabeth

AU - Martini, Alessandra

AU - Nation, Daniel A.

PY - 2022/12

Y1 - 2022/12

N2 - Blood pressure variability is an emerging risk factor for Alzheimer’s disease in older adults, independent of average blood pressure levels. Growing evidence suggests increased blood pressure variability is linked to Alzheimer’s disease pathophysiology indexed by cerebrospinal fluid and positron emission tomography markers, but relationships with plasma Alzheimer’s disease markers have not been investigated. In this cross-sectional study of 54 community-dwelling older adults (aged 55–88, mean age 69.9 [8.2 SD]), elevated blood pressure variability over 5 min was associated with lower levels of plasma Aβ1–42 (standardized ß = − 0.36 [95% CI − 0.61, − 0.12]; p = 0.005; adjusted R2 = 0.28) and Aβ1–42: Aβ1–40 ratio (ß = − 0.49 [95% CI − 0.71, − 0.22]; p < 0.001; adjusted R2 = 0.28), and higher levels of total tau (ß = 0.27 [95% CI 0.01, 0.54]; p = 0.04; adjusted R2 = 0.19) and Ptau181:Aβ1–42 ratio (ß = 0.26 [95% CI 0.02, 0.51]; p = 0.04; adjusted R2 = 0.22). Findings suggest higher blood pressure variability is linked to plasma biomarkers of increased Alzheimer’s disease pathophysiology.

AB - Blood pressure variability is an emerging risk factor for Alzheimer’s disease in older adults, independent of average blood pressure levels. Growing evidence suggests increased blood pressure variability is linked to Alzheimer’s disease pathophysiology indexed by cerebrospinal fluid and positron emission tomography markers, but relationships with plasma Alzheimer’s disease markers have not been investigated. In this cross-sectional study of 54 community-dwelling older adults (aged 55–88, mean age 69.9 [8.2 SD]), elevated blood pressure variability over 5 min was associated with lower levels of plasma Aβ1–42 (standardized ß = − 0.36 [95% CI − 0.61, − 0.12]; p = 0.005; adjusted R2 = 0.28) and Aβ1–42: Aβ1–40 ratio (ß = − 0.49 [95% CI − 0.71, − 0.22]; p < 0.001; adjusted R2 = 0.28), and higher levels of total tau (ß = 0.27 [95% CI 0.01, 0.54]; p = 0.04; adjusted R2 = 0.19) and Ptau181:Aβ1–42 ratio (ß = 0.26 [95% CI 0.02, 0.51]; p = 0.04; adjusted R2 = 0.22). Findings suggest higher blood pressure variability is linked to plasma biomarkers of increased Alzheimer’s disease pathophysiology.

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Blood pressure variability and plasma Alzheimer’s disease biomarkers in older adults

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