Blood pressure control in aging predicts cerebral atrophy related to small-vessel white matter lesions

Kyle C. Kern, Clinton B. Wright, Kaitlin L. Bergfield, Megan C. Fitzhugh, Kewei Chen, James R. Moeller, Nooshin Nabizadeh, Mitchell S.V. Elkind, Ralph L. Sacco, Yaakov Stern, Charles S. DeCarli, Gene E. Alexander

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Cerebral small-vessel damage manifests as white matter hyperintensities and cerebral atrophy on brain MRI and is associated with aging, cognitive decline and dementia. We sought to examine the interrelationship of these imaging biomarkers and the influence of hypertension in older individuals. We used a multivariate spatial covariance neuroimaging technique to localize the effects of white matter lesion load on regional gray matter volume and assessed the role of blood pressure control, age and education on this relationship. Using a case-control design matching for age, gender, and educational attainment we selected 64 participants with normal blood pressure, controlled hypertension or uncontrolled hypertension from the Northern Manhattan Study cohort. We applied gray matter voxel-based morphometry with the scaled subprofile model to (1) identify regional covariance patterns of gray matter volume differences associated with white matter lesion load, (2) compare this relationship across blood pressure groups, and (3) relate it to cognitive performance. In this group of participants aged 60-86 years, we identified a pattern of reduced gray matter volume associated with white matter lesion load in bilateral temporal-parietal regions with relative preservation of volume in the basal forebrain, thalami and cingulate cortex. This pattern was expressed most in the uncontrolled hypertension group and least in the normotensives, but was also more evident in older and more educated individuals. Expression of this pattern was associated with worse performance in executive function and memory. In summary, white matter lesions from small-vessel disease are associated with a regional pattern of gray matter atrophy that is mitigated by blood pressure control, exacerbated by aging, and associated with cognitive performance.

Original languageEnglish (US)
Article number132
JournalFrontiers in Aging Neuroscience
Issue numberMAY
StatePublished - May 15 2017


  • Aging
  • Brain atrophy
  • Cerebrovascular disease
  • Cognition
  • Hypertension
  • Scaled subprofile model
  • Voxel-based morphometry
  • White matter hyperintensities

ASJC Scopus subject areas

  • Aging
  • Cognitive Neuroscience


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