@article{616ea9a97026418c88482faf8989b06f,
title = "Blood group-related antigens as markers of malignant potential and heterogeneity in human carcinomas",
abstract = "The expression of BGR-Ags is often aberrant in human carcinomas. The observation that BGR-Ag expression in human bladder carcinomas correlates with prognosis for patients with these tumors is especially interesting in light of the numerous reports of correlations between cell surface glycosylation and malignant phenotype in experimental animal tumors. Many observations suggest how this relation might be mediated. It seems reasonable to anticipate that the study of the BGR-Ags and their expression in carcinoma may emerge from its current predominantly descriptive phase and become an important part of the investigation of human tumor biology.",
author = "Conn, {John S.} and Weinstein, {Ronald S.}",
note = "Funding Information: A variety of aherations in BGR-Ag expression on carcinoma cells, compared with the corresponding normal epithelium, have been reported, but they can be conveniently classified into two categories: 1) deletion of BGR-Ags normally expressed and 2) emergence of antigens not present on normal epithelial cells, s.s Many of the abnormal antigens are cryptan-tigens marked by terminal sugar residues in normal tissue. Cell surface carbohydrate antigens are formed by the sequential addition of sugar residues to precursor structures by specific glycosyhransferases. ~ Incomplete synthesis or partial degradation of oligosaccharide chains can thus result in both deletion of College, Chicago, Illinois. Accepted for publication June 19, 1986. Supported in part by research grants CA-34074 and CA-41040 from the National Cancer Institute. Address correspondence and reprint requests to Dr. Wein-stein: Professor and Chairman_Departnaent of Pathology, Rush Medical College, 17_53W . Congress Parkwa)', Chicago, IL 60612. 00-t6-8177/86 $0.00 + .25 normal BGR-Ags and expression of abnormal precursor structures. However, many of the aberrant BGR-Ags described on tumor cells, e.g., expression of the A antigen in a person of B genetic background, 8 cannot be explained by simple shortening of otherwise normal oligosaccharide chains (see below).",
year = "1986",
month = nov,
doi = "10.1016/S0046-8177(86)80413-0",
language = "English (US)",
volume = "17",
pages = "1089--1106",
journal = "Human pathology",
issn = "0046-8177",
publisher = "W.B. Saunders Ltd",
number = "11",
}