Blast Exposure Disrupts the Tonotopic Frequency Map in the Primary Auditory Cortex

Samer Masri, Li S. Zhang, Hao Luo, Edward Pace, Jinsheng Zhang, Shaowen Bao

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Blast exposure can cause various auditory disorders including tinnitus, hyperacusis, and other central auditory processing disorders. While this is suggestive of pathologies in the central auditory system, the impact of blast exposure on central auditory processing remains poorly understood. Here we examined the effects of blast shockwaves on acoustic response properties and the tonotopic frequency map in the auditory cortex. We found that multiunits recorded from the auditory cortex exhibited higher acoustic thresholds and broader frequency tuning in blast-exposed animals. Furthermore, the frequency map in the primary auditory cortex was distorted. These changes may contribute to central auditory processing disorders.

Original languageEnglish (US)
Pages (from-to)428-434
Number of pages7
JournalNeuroscience
Volume379
DOIs
StatePublished - May 21 2018

Keywords

  • auditory cortex
  • blast
  • central auditory processing disorder
  • frequency map
  • rat

ASJC Scopus subject areas

  • Neuroscience(all)

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