@article{bfb5fa21d1864d2ab7bc073d2fa4078a,
title = "Biosynthesis of the antitumor antibiotic anthramycin by Streptomyces refuineus",
abstract = "The biogenetic building blocks for anthramycin have been established as tryptophan, tyrosine, and two one-carbon units via methionine.",
author = "Hurley, \{Laurence H.\} and M. Zmijewski",
note = "Funding Information: Julius Berger of Hoffmann-La Roche Company for providing us with a gift of anthramycin and information on suitable conditions for anthramycin pro- duction. We also thank Dr. U. Hornemann of Purdue University for useful discussion and Dr. K. L. Perlman of Wisconsin University for supplying us with MHAA. This work was aided by an Institutional Grant from the Ameri- can Cancer Society. (Received, 28th, December 1973; Com. 1732.) t The conclusion is valid if no NIH shift has taken place in the conversion of tyrosine into dopa. The absence of such a shift during this transformation has, in fact been shown in other systems. (J. W. Daly, D. M. Jerina, and B. Witkop, Experientia, 1972,28, 1128.) 1 M. D. Tendler and S. Korman, Nature, 1963, 199, 601; W. Leimgruber, A. D. Batcho, and F. Schenker, J. Amer. Chem. Soc., 1965, 87, 5793; W. Leimgruber, V. Stefanovic, F. Schenker, A. Karr, and J. Berger, ibid.,p. 6791. 2 L. Salzmann, H. Weissbach, and E. Katz, Arch. Biochem. Biofihys., 1969, 130, 536. 8 D. M. Greenberg in {\textquoteleft}Metabolic Pathways,{\textquoteright} ed. D. M. Greenberg, vol. I, p. 153, Academic Press, New York, 1969. 4 D. F. Witz, E. J. Hessler, and T. L. Miller, Biockem., 1971, 10, 1128.",
year = "1974",
doi = "10.1039/C39740000337",
language = "English (US)",
pages = "337--338",
journal = "Journal of the Chemical Society, Chemical Communications",
issn = "0022-4936",
publisher = "Royal Society of Chemistry",
number = "9",
}