Biosynthesis of pyrrolopyrimidines

Reid M. McCarty; Vahe Bandarian

doi:10.1016/j.bioorg.2012.01.001

Biosynthesis of pyrrolopyrimidines

Reid M. McCarty, Vahe Bandarian

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Pyrrolopyrimidine containing compounds, also known as 7-deazapurines, are a collection of purine-based metabolites that have been isolated from a variety of biological sources and have diverse functions which range from secondary metabolism to RNA modification. To date, nearly 35 compounds with the common 7-deazapurine core structure have been described. This article will illustrate the structural diversity of these compounds and review the current state of knowledge on the biosynthetic pathways that give rise to them.

Original language	English (US)
Pages (from-to)	15-25
Number of pages	11
Journal	Bioorganic Chemistry
Volume	43
DOIs	https://doi.org/10.1016/j.bioorg.2012.01.001
State	Published - Aug 2012

Keywords

7-Deazapurine in secondary metabolism
7-Deazapurines in tRNA
Biosynthesis of 7-deazapurines

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Drug Discovery
Organic Chemistry

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10.1016/j.bioorg.2012.01.001

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title = "Biosynthesis of pyrrolopyrimidines",

abstract = "Pyrrolopyrimidine containing compounds, also known as 7-deazapurines, are a collection of purine-based metabolites that have been isolated from a variety of biological sources and have diverse functions which range from secondary metabolism to RNA modification. To date, nearly 35 compounds with the common 7-deazapurine core structure have been described. This article will illustrate the structural diversity of these compounds and review the current state of knowledge on the biosynthetic pathways that give rise to them.",

keywords = "7-Deazapurine in secondary metabolism, 7-Deazapurines in tRNA, Biosynthesis of 7-deazapurines",

author = "McCarty, {Reid M.} and Vahe Bandarian",

note = "Funding Information: V.B. is grateful for National Institutes of Health (NIH) (GM72623) and Burroughs Wellcome Fund for funding various aspects of the work. R.M.M. acknowledges support from Biological Chemistry Training grant from NIH (T32 GM008804) and Science Foundation Arizona for a Graduate Fellowship.",

year = "2012",

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doi = "10.1016/j.bioorg.2012.01.001",

language = "English (US)",

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journal = "Bioorganic Chemistry",

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AU - McCarty, Reid M.

AU - Bandarian, Vahe

N1 - Funding Information: V.B. is grateful for National Institutes of Health (NIH) (GM72623) and Burroughs Wellcome Fund for funding various aspects of the work. R.M.M. acknowledges support from Biological Chemistry Training grant from NIH (T32 GM008804) and Science Foundation Arizona for a Graduate Fellowship.

PY - 2012/8

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N2 - Pyrrolopyrimidine containing compounds, also known as 7-deazapurines, are a collection of purine-based metabolites that have been isolated from a variety of biological sources and have diverse functions which range from secondary metabolism to RNA modification. To date, nearly 35 compounds with the common 7-deazapurine core structure have been described. This article will illustrate the structural diversity of these compounds and review the current state of knowledge on the biosynthetic pathways that give rise to them.

AB - Pyrrolopyrimidine containing compounds, also known as 7-deazapurines, are a collection of purine-based metabolites that have been isolated from a variety of biological sources and have diverse functions which range from secondary metabolism to RNA modification. To date, nearly 35 compounds with the common 7-deazapurine core structure have been described. This article will illustrate the structural diversity of these compounds and review the current state of knowledge on the biosynthetic pathways that give rise to them.

KW - 7-Deazapurine in secondary metabolism

KW - 7-Deazapurines in tRNA

KW - Biosynthesis of 7-deazapurines

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JO - Bioorganic Chemistry

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Biosynthesis of pyrrolopyrimidines

Abstract

Keywords

ASJC Scopus subject areas

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