Biomechanical properties of recurrent laryngeal nerve in the piglet

Megan J. Alexander; Julie M. Barkmeier-Kraemer; Jonathan P.Vande Geest

doi:10.1007/s10439-010-0013-7

Biomechanical properties of recurrent laryngeal nerve in the piglet

Megan J. Alexander, Julie M. Barkmeier-Kraemer, Jonathan P.Vande Geest

Aerospace and Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Unilateral vocal fold paralysis (UVP) results from damage to the recurrent laryngeal nerve (RLN). The most common causes of UVP are associated with compromised RLN tissue. The purpose of this research was to investigate the biomechanical properties of piglet RLN and identify differences in these properties along its length and in between the left and right side. Quasi-static uniaxial tensile testing and isotropic constitutive modeling was performed on seven piglet RLNs. Stiffness and other biomechanical parameters were derived from these tests and compared from conducting two different statistical analysis for the between and within nerve comparisons. Results showed higher stiffness values in the left RLN segment than for the right. Descriptive data demonstrated a higher stiffness in RLN segments surrounding the aortic arch, indicating a more protective role of the extracellular matrix in these nerves. This research offers insight regarding the protective function of the RLN connective tissues and structural compromise due to its environment.

Original language	English (US)
Pages (from-to)	2553-2562
Number of pages	10
Journal	Annals of Biomedical Engineering
Volume	38
Issue number	8
DOIs	https://doi.org/10.1007/s10439-010-0013-7
State	Published - Aug 2010

Keywords

Epineurium
Mechanical properties
Ortner's syndrome
Stiffness
Unilateral vocal fold paralysis
Yield stress

ASJC Scopus subject areas

Biomedical Engineering

Access to Document

10.1007/s10439-010-0013-7

Cite this

@article{5e3987878fc64dfda074c5dc69d0a9a0,

title = "Biomechanical properties of recurrent laryngeal nerve in the piglet",

abstract = "Unilateral vocal fold paralysis (UVP) results from damage to the recurrent laryngeal nerve (RLN). The most common causes of UVP are associated with compromised RLN tissue. The purpose of this research was to investigate the biomechanical properties of piglet RLN and identify differences in these properties along its length and in between the left and right side. Quasi-static uniaxial tensile testing and isotropic constitutive modeling was performed on seven piglet RLNs. Stiffness and other biomechanical parameters were derived from these tests and compared from conducting two different statistical analysis for the between and within nerve comparisons. Results showed higher stiffness values in the left RLN segment than for the right. Descriptive data demonstrated a higher stiffness in RLN segments surrounding the aortic arch, indicating a more protective role of the extracellular matrix in these nerves. This research offers insight regarding the protective function of the RLN connective tissues and structural compromise due to its environment.",

keywords = "Epineurium, Mechanical properties, Ortner's syndrome, Stiffness, Unilateral vocal fold paralysis, Yield stress",

author = "Alexander, {Megan J.} and Barkmeier-Kraemer, {Julie M.} and Geest, {Jonathan P.Vande}",

note = "Funding Information: We would like to thank Mark Borgstrom for conducting the statistical analysis. Robin Samlan also contributed to planning the study and contributing to hypotheses regarding biomechanical properties from histologic work in her research. Joshua Lopez contributed to piglet tissue acquisition. Megan Alexander{\textquoteright}s research was partially supported by a UA/NASA Space Grant Undergraduate Research Internship.",

year = "2010",

month = aug,

doi = "10.1007/s10439-010-0013-7",

language = "English (US)",

volume = "38",

pages = "2553--2562",

journal = "Annals of Biomedical Engineering",

issn = "0090-6964",

publisher = "Springer",

number = "8",

}

TY - JOUR

T1 - Biomechanical properties of recurrent laryngeal nerve in the piglet

AU - Alexander, Megan J.

AU - Barkmeier-Kraemer, Julie M.

AU - Geest, Jonathan P.Vande

N1 - Funding Information: We would like to thank Mark Borgstrom for conducting the statistical analysis. Robin Samlan also contributed to planning the study and contributing to hypotheses regarding biomechanical properties from histologic work in her research. Joshua Lopez contributed to piglet tissue acquisition. Megan Alexander’s research was partially supported by a UA/NASA Space Grant Undergraduate Research Internship.

PY - 2010/8

Y1 - 2010/8

N2 - Unilateral vocal fold paralysis (UVP) results from damage to the recurrent laryngeal nerve (RLN). The most common causes of UVP are associated with compromised RLN tissue. The purpose of this research was to investigate the biomechanical properties of piglet RLN and identify differences in these properties along its length and in between the left and right side. Quasi-static uniaxial tensile testing and isotropic constitutive modeling was performed on seven piglet RLNs. Stiffness and other biomechanical parameters were derived from these tests and compared from conducting two different statistical analysis for the between and within nerve comparisons. Results showed higher stiffness values in the left RLN segment than for the right. Descriptive data demonstrated a higher stiffness in RLN segments surrounding the aortic arch, indicating a more protective role of the extracellular matrix in these nerves. This research offers insight regarding the protective function of the RLN connective tissues and structural compromise due to its environment.

AB - Unilateral vocal fold paralysis (UVP) results from damage to the recurrent laryngeal nerve (RLN). The most common causes of UVP are associated with compromised RLN tissue. The purpose of this research was to investigate the biomechanical properties of piglet RLN and identify differences in these properties along its length and in between the left and right side. Quasi-static uniaxial tensile testing and isotropic constitutive modeling was performed on seven piglet RLNs. Stiffness and other biomechanical parameters were derived from these tests and compared from conducting two different statistical analysis for the between and within nerve comparisons. Results showed higher stiffness values in the left RLN segment than for the right. Descriptive data demonstrated a higher stiffness in RLN segments surrounding the aortic arch, indicating a more protective role of the extracellular matrix in these nerves. This research offers insight regarding the protective function of the RLN connective tissues and structural compromise due to its environment.

KW - Epineurium

KW - Mechanical properties

KW - Ortner's syndrome

KW - Stiffness

KW - Unilateral vocal fold paralysis

KW - Yield stress

UR - http://www.scopus.com/inward/record.url?scp=77955171266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955171266&partnerID=8YFLogxK

U2 - 10.1007/s10439-010-0013-7

DO - 10.1007/s10439-010-0013-7

M3 - Article

C2 - 20369296

AN - SCOPUS:77955171266

SN - 0090-6964

VL - 38

SP - 2553

EP - 2562

JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

IS - 8

ER -

Biomechanical properties of recurrent laryngeal nerve in the piglet

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this