Biomarkers of gut barrier dysfunction in obstructive sleep apnea: A systematic review and meta-analysis

Saif Mashaqi, Pooja Rangan, Ahlam A. Saleh, Ivo Abraham, David Gozal, Stuart F. Quan, Sairam Parthasarathy

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

We conducted this systematic review and meta-analysis to evaluate the impact of obstructive sleep apnea (OSA) on gut barrier dysfunction as represented by the following biomarkers: zonulin, lipopolysaccharide, lipopolysaccharide binding protein, intestinal fatty acid binding protein, and lactic acid. A comprehensive search of the literature was conducted in Ovid MEDLINE, Embase, Scopus, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov without language restrictions from inception to October 2022. The analysis of all outcomes was performed using a random-effects model. We included eight studies (seven cross sectional and one case control) in the final quantitative synthesis with a total of 897 patients. We concluded that OSA was associated with higher levels of gut barrier dysfunction biomarkers [Hedges’ g = 0.73 (95%CI 0.37–1.09, p < 0.01). Biomarker levels were positively correlated with the apnea-hypopnea index [r = 0.48 (95%CI 0.35–0.6, p < 0.01)] and oxygen desaturation index [r = 0.30 (95%CI 0.17–0.42, p < 0.01)], and negatively correlated with the nadir oxygen desaturation values [r = −0.45 (95%CI - 0.55 – - 0.32, p < 0.01). Our systematic review and meta-analysis suggests that OSA is associated with gut barrier dysfunction. Furthermore, OSA severity appears to be correlated with higher biomarkers of gut barrier dysfunction. Prospero registration number: CRD42022333078.

Original languageEnglish (US)
Article number101774
JournalSleep Medicine Reviews
Volume69
DOIs
StatePublished - Jun 2023

Keywords

  • Apnea-hypopnea index
  • Biomarkers
  • Gut barrier dysfunction
  • Nadir SpO2
  • Obstructive sleep apnea
  • Oxygen desaturation index

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Fingerprint

Dive into the research topics of 'Biomarkers of gut barrier dysfunction in obstructive sleep apnea: A systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this