TY - JOUR
T1 - Biomarkers for cognitive aging part II
T2 - Oxidative stress, cognitive assessments, and medication adherence
AU - Insel, Kathleen C.
AU - Moore, Ida M.
AU - Vidrine, Amy N.
AU - Montgomery, David W.
N1 - Funding Information:
The authors disclosed receipt of the following financial support for the research and/or authorship of this article: This research was supported by the National Institutes of Health, R03 NR010010-01.
PY - 2012/4
Y1 - 2012/4
N2 - The purpose of this study was to further examine potential biomarkers of cognitive aging by looking at the associations among oxidative stress, cognitive abilities, and medication adherence in a community-based sample of middle-aged and older adults (n = 42; mean age = 69 years) prescribed at least one medication for hypertension. In addition to measures described in Part I, "Biomarkers for Cognitive Aging," a 12-hr urine collection for F2-isoprostanes served as an indicator of oxidative stress. Participants completed a battery of cognitive assessments and 8 weeks of electronic medication monitoring for adherence to one antihypertensive agent. Oxidative stress was significantly associated with logical memory, immediate (r = -.38, p < .01) and delayed recall (r = -.42, p < .01), and recognition memory (r = -.42, p < .01) from the Wechsler Memory Scale III, number of perseveration errors (r =.26, p < .05) and categories achieved (r = -.26, p < .01) on the Wisconsin Card Sorting Test (WSCT), and medication adherence (r = -.34, p < .05). Findings indicate that a biomarker of oxidative stress, F2-isoprostanes corrected for vitamin E, is significantly associated with cognitive measures and a functional outcome.
AB - The purpose of this study was to further examine potential biomarkers of cognitive aging by looking at the associations among oxidative stress, cognitive abilities, and medication adherence in a community-based sample of middle-aged and older adults (n = 42; mean age = 69 years) prescribed at least one medication for hypertension. In addition to measures described in Part I, "Biomarkers for Cognitive Aging," a 12-hr urine collection for F2-isoprostanes served as an indicator of oxidative stress. Participants completed a battery of cognitive assessments and 8 weeks of electronic medication monitoring for adherence to one antihypertensive agent. Oxidative stress was significantly associated with logical memory, immediate (r = -.38, p < .01) and delayed recall (r = -.42, p < .01), and recognition memory (r = -.42, p < .01) from the Wechsler Memory Scale III, number of perseveration errors (r =.26, p < .05) and categories achieved (r = -.26, p < .01) on the Wisconsin Card Sorting Test (WSCT), and medication adherence (r = -.34, p < .05). Findings indicate that a biomarker of oxidative stress, F2-isoprostanes corrected for vitamin E, is significantly associated with cognitive measures and a functional outcome.
KW - adherence
KW - cognition
KW - hypertension
KW - oxidative stress
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U2 - 10.1177/1099800411406527
DO - 10.1177/1099800411406527
M3 - Article
C2 - 21586493
AN - SCOPUS:84859765743
SN - 1099-8004
VL - 14
SP - 133
EP - 138
JO - Biological Research for Nursing
JF - Biological Research for Nursing
IS - 2
ER -