Biomarkers and Cognitive Function in Children and Adolescents During Maintenance Therapy for Leukemia

Mary C. Hooke; Michelle A. Mathiason; Alicia S. Kunin-Batson; Audrey Blommer; Jessica Hutter; Pauline A. Mitby; Ida M. Moore; Susan Whitman; Olga Taylor; Michael E. Scheurer; Marilyn J. Hockenberry

doi:10.1188/21.ONF.623-633

Biomarkers and Cognitive Function in Children and Adolescents During Maintenance Therapy for Leukemia

Mary C. Hooke, Michelle A. Mathiason, Alicia S. Kunin-Batson, Audrey Blommer, Jessica Hutter, Pauline A. Mitby, Ida M. Moore, Susan Whitman, Olga Taylor, Michael E. Scheurer, Marilyn J. Hockenberry

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

OBJECTIVES: To explore the relationship between biomarkers of oxidative stress and inflmmation in cerebrospinal fluid (CSF) and cognitive function in children receiving maintenance therapy for acute lymphocytic leukemia (ALL). SAMPLE & SETTING: 30 participants aged 4-17 years receiving ALL maintenance therapy at two pediatric cancer centers in the United States. METHODS & VARIABLES: F2-isoprostane (F2-ISoP) and interleukin-8 (IL-8) were evaluated in CSF samples, and cognitive function measures were completed during the first and last cycles of ALL maintenance. The Flanker Inhibitory Control and Attention Test (Flanker) and Dimensional Change Card Sort were completed during the last cycle. RESULTS: During maintenance therapy, IL-8 decreased, and parent reports of children's cognitive function improved. Higher IL-8 was associated with better parent reports of children's cognitive function at each timepoint. Higher F2-ISoP levels were associated with lower Flanker scores. IMPLICATIONS FOR NURSING: F2-ISoP may be a useful biomarker in evaluating cognitive dysfunction in children with ALL and merits further investigation.

Original language	English (US)
Pages (from-to)	623-633
Number of pages	11
Journal	Oncology nursing forum
Volume	48
Issue number	6
DOIs	https://doi.org/10.1188/21.ONF.623-633
State	Published - Nov 2021
Externally published	Yes

Keywords

Acute lymphoblastic leukemia
Biomarkers
Childhood cancer
Cognitive function

ASJC Scopus subject areas

Oncology(nursing)

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10.1188/21.ONF.623-633

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@article{0ce3c69c78ea47a39eba4773591b8a96,

title = "Biomarkers and Cognitive Function in Children and Adolescents During Maintenance Therapy for Leukemia",

abstract = "OBJECTIVES: To explore the relationship between biomarkers of oxidative stress and inflmmation in cerebrospinal fluid (CSF) and cognitive function in children receiving maintenance therapy for acute lymphocytic leukemia (ALL). SAMPLE & SETTING: 30 participants aged 4-17 years receiving ALL maintenance therapy at two pediatric cancer centers in the United States. METHODS & VARIABLES: F2-isoprostane (F2-ISoP) and interleukin-8 (IL-8) were evaluated in CSF samples, and cognitive function measures were completed during the first and last cycles of ALL maintenance. The Flanker Inhibitory Control and Attention Test (Flanker) and Dimensional Change Card Sort were completed during the last cycle. RESULTS: During maintenance therapy, IL-8 decreased, and parent reports of children's cognitive function improved. Higher IL-8 was associated with better parent reports of children's cognitive function at each timepoint. Higher F2-ISoP levels were associated with lower Flanker scores. IMPLICATIONS FOR NURSING: F2-ISoP may be a useful biomarker in evaluating cognitive dysfunction in children with ALL and merits further investigation.",

keywords = "Acute lymphoblastic leukemia, Biomarkers, Childhood cancer, Cognitive function",

author = "Hooke, {Mary C.} and Mathiason, {Michelle A.} and Kunin-Batson, {Alicia S.} and Audrey Blommer and Jessica Hutter and Mitby, {Pauline A.} and Moore, {Ida M.} and Susan Whitman and Olga Taylor and Scheurer, {Michael E.} and Hockenberry, {Marilyn J.}",

year = "2021",

month = nov,

doi = "10.1188/21.ONF.623-633",

language = "English (US)",

volume = "48",

pages = "623--633",

journal = "Oncology nursing forum",

issn = "0190-535X",

publisher = "Oncology Nursing Society",

number = "6",

}

TY - JOUR

T1 - Biomarkers and Cognitive Function in Children and Adolescents During Maintenance Therapy for Leukemia

AU - Hooke, Mary C.

AU - Mathiason, Michelle A.

AU - Kunin-Batson, Alicia S.

AU - Blommer, Audrey

AU - Hutter, Jessica

AU - Mitby, Pauline A.

AU - Moore, Ida M.

AU - Whitman, Susan

AU - Taylor, Olga

AU - Scheurer, Michael E.

AU - Hockenberry, Marilyn J.

PY - 2021/11

Y1 - 2021/11

N2 - OBJECTIVES: To explore the relationship between biomarkers of oxidative stress and inflmmation in cerebrospinal fluid (CSF) and cognitive function in children receiving maintenance therapy for acute lymphocytic leukemia (ALL). SAMPLE & SETTING: 30 participants aged 4-17 years receiving ALL maintenance therapy at two pediatric cancer centers in the United States. METHODS & VARIABLES: F2-isoprostane (F2-ISoP) and interleukin-8 (IL-8) were evaluated in CSF samples, and cognitive function measures were completed during the first and last cycles of ALL maintenance. The Flanker Inhibitory Control and Attention Test (Flanker) and Dimensional Change Card Sort were completed during the last cycle. RESULTS: During maintenance therapy, IL-8 decreased, and parent reports of children's cognitive function improved. Higher IL-8 was associated with better parent reports of children's cognitive function at each timepoint. Higher F2-ISoP levels were associated with lower Flanker scores. IMPLICATIONS FOR NURSING: F2-ISoP may be a useful biomarker in evaluating cognitive dysfunction in children with ALL and merits further investigation.

AB - OBJECTIVES: To explore the relationship between biomarkers of oxidative stress and inflmmation in cerebrospinal fluid (CSF) and cognitive function in children receiving maintenance therapy for acute lymphocytic leukemia (ALL). SAMPLE & SETTING: 30 participants aged 4-17 years receiving ALL maintenance therapy at two pediatric cancer centers in the United States. METHODS & VARIABLES: F2-isoprostane (F2-ISoP) and interleukin-8 (IL-8) were evaluated in CSF samples, and cognitive function measures were completed during the first and last cycles of ALL maintenance. The Flanker Inhibitory Control and Attention Test (Flanker) and Dimensional Change Card Sort were completed during the last cycle. RESULTS: During maintenance therapy, IL-8 decreased, and parent reports of children's cognitive function improved. Higher IL-8 was associated with better parent reports of children's cognitive function at each timepoint. Higher F2-ISoP levels were associated with lower Flanker scores. IMPLICATIONS FOR NURSING: F2-ISoP may be a useful biomarker in evaluating cognitive dysfunction in children with ALL and merits further investigation.

KW - Acute lymphoblastic leukemia

KW - Biomarkers

KW - Childhood cancer

KW - Cognitive function

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Biomarkers and Cognitive Function in Children and Adolescents During Maintenance Therapy for Leukemia

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