Biological and Computational Techniques to Identify Mitochondrial Toxicants

Robert B. Cameron, Craig C. Beeson, Rick G. Schnellmann

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Mitochondrial toxicity is a common cause of drug toxicity and failure in clinical trials. To prevent unwanted mitochondrial toxicity in new drugs, high-throughput screening techniques for mitochondrial toxicity must be developed and implemented. In particular, measuring oxygen consumption rate (OCR) allows for the rapid testing of compounds for mitochondrial toxicity and the identification of mechanisms of mitochondrial toxicity. Additionally, in silico techniques such as quantitative structure-activity relationship (QSAR) and toxicophore modeling can identify chemical features that cause mitochondrial toxicity. This chapter summarizes methods for testing mitochondrial toxicity with an emphasis on the advantages and challenges of measuring OCR and provides an overview of the application of QSAR and toxicophore models to mitochondrial toxicity.

Original languageEnglish (US)
Title of host publicationMitochondrial Dysfunction Caused by Drugs and Environmental Toxicants
PublisherWiley
Pages205-215
Number of pages11
Volume1-2
ISBN (Electronic)9781119329725
ISBN (Print)9781119329701
DOIs
StatePublished - Feb 21 2018

Keywords

  • Drug development
  • Electron transport chain
  • Mitochondrial toxicity
  • Oxygen consumption rate
  • QSAR
  • Toxicity screening
  • Toxicophore

ASJC Scopus subject areas

  • Chemistry(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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