Biological activity of some coumarins from Sri Lankan rutaceae

A. A.Leslie Gunatilaka; David G.I. Kingston; E. M.Kithsiri Wijeratne; B. M.Ratnayake Bandara; Glenn A. Hofmann; Randall K. Johnson

doi:10.1021/np50106a013

Biological activity of some coumarins from Sri Lankan rutaceae

A. A.Leslie Gunatilaka, David G.I. Kingston, E. M.Kithsiri Wijeratne, B. M.Ratnayake Bandara, Glenn A. Hofmann, Randall K. Johnson

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

Twelve coumarins isolated from plants of the Rutaceae collected in Sri Lanka have been subjected to a mechanism-based anticancer bioassay employing DNA repair-deficient and repair-proficient yeasts. Of these, seselin [10] and xanthyletin [11] were found to be active. Seselin also exhibited moderate cytotoxicity.

Original language	English (US)
Pages (from-to)	518-520
Number of pages	3
Journal	Journal Of Natural Products
Volume	57
Issue number	4
DOIs	https://doi.org/10.1021/np50106a013
State	Published - Apr 1 1994
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np50106a013

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title = "Biological activity of some coumarins from Sri Lankan rutaceae",

abstract = "Twelve coumarins isolated from plants of the Rutaceae collected in Sri Lanka have been subjected to a mechanism-based anticancer bioassay employing DNA repair-deficient and repair-proficient yeasts. Of these, seselin [10] and xanthyletin [11] were found to be active. Seselin also exhibited moderate cytotoxicity.",

author = "Gunatilaka, {A. A.Leslie} and Kingston, {David G.I.} and Wijeratne, {E. M.Kithsiri} and Bandara, {B. M.Ratnayake} and Hofmann, {Glenn A.} and Johnson, {Randall K.}",

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AU - Gunatilaka, A. A.Leslie

AU - Kingston, David G.I.

AU - Wijeratne, E. M.Kithsiri

AU - Bandara, B. M.Ratnayake

AU - Hofmann, Glenn A.

AU - Johnson, Randall K.

PY - 1994/4/1

Y1 - 1994/4/1

N2 - Twelve coumarins isolated from plants of the Rutaceae collected in Sri Lanka have been subjected to a mechanism-based anticancer bioassay employing DNA repair-deficient and repair-proficient yeasts. Of these, seselin [10] and xanthyletin [11] were found to be active. Seselin also exhibited moderate cytotoxicity.

AB - Twelve coumarins isolated from plants of the Rutaceae collected in Sri Lanka have been subjected to a mechanism-based anticancer bioassay employing DNA repair-deficient and repair-proficient yeasts. Of these, seselin [10] and xanthyletin [11] were found to be active. Seselin also exhibited moderate cytotoxicity.

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Biological activity of some coumarins from Sri Lankan rutaceae

Abstract

ASJC Scopus subject areas

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