Biological activity of some coumarins from Sri Lankan rutaceae

A. A.Leslie Gunatilaka, David G.I. Kingston, E. M.Kithsiri Wijeratne, B. M.Ratnayake Bandara, Glenn A. Hofmann, Randall K. Johnson

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


Twelve coumarins isolated from plants of the Rutaceae collected in Sri Lanka have been subjected to a mechanism-based anticancer bioassay employing DNA repair-deficient and repair-proficient yeasts. Of these, seselin [10] and xanthyletin [11] were found to be active. Seselin also exhibited moderate cytotoxicity.

Original languageEnglish (US)
Pages (from-to)518-520
Number of pages3
JournalJournal Of Natural Products
Issue number4
StatePublished - Apr 1 1994

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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