Biochemical genesis of enzymatic and non-enzymatic post-translational modifications

Erin Q. Jennings, Kristofer S. Fritz, James J. Galligan

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Post-translational modifications (PTMs) alter protein structure, function, and localization and play a pivotal role in physiological and pathophysiological conditions. Many PTMs arise from endogenous metabolic intermediates and serve as sensors for metabolic feedback to maintain cell growth and homeostasis. A key feature to PTMs is their biochemical genesis, which can result from either non-enzymatic adduction (nPTMs) or through enzyme-catalyzed reactions (ePTMs). The abundance and site-specificity of PTMs are determined by dedicated classes of enzymes that add (writers) or remove (erasers) the chemical addition. In this review we will highlight the biochemical genesis and regulation of a few of the 700+ PTMs that have been identified.

Original languageEnglish (US)
Article number101053
JournalMolecular Aspects of Medicine
StatePublished - Aug 2022


  • Acylation
  • Glycation
  • Glycosylation
  • Glyoxalase
  • Metabolism
  • Sirtuin
  • Sulfenylation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry


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