Bioactive steroidal alkaloids from Solanum umbelliferum

Youn C. Kim; Qing Ming Che; A. A.Leslie Gunatilaka; David G.I. Kingston

doi:10.1021/np960125a

Bioactive steroidal alkaloids from Solanum umbelliferum

Youn C. Kim
, Qing Ming Che
, A. A.Leslie Gunatilaka
, David G.I. Kingston

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Bioassay-directed fractionation of the MeOH extract of Solanum umbelliferum afforded solasodine (1), O-acetylsolasodine (2), and solasodine 3-O-β-D-glucopyranoside (3). Alkaloids 1 and 2 exhibited significant activity toward DNA repair-deficient yeast mutants, whereas 3 and the synthetic analogues N-acetylsolasodine (4) and N,O-diacetylsolasodine (5) were found to be inactive. Compounds 2 and 3 are new natural products.

Original language	English (US)
Pages (from-to)	283-285
Number of pages	3
Journal	Journal Of Natural Products
Volume	59
Issue number	3
DOIs	https://doi.org/10.1021/np960125a
State	Published - Mar 1996
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np960125a

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title = "Bioactive steroidal alkaloids from Solanum umbelliferum",

abstract = "Bioassay-directed fractionation of the MeOH extract of Solanum umbelliferum afforded solasodine (1), O-acetylsolasodine (2), and solasodine 3-O-β-D-glucopyranoside (3). Alkaloids 1 and 2 exhibited significant activity toward DNA repair-deficient yeast mutants, whereas 3 and the synthetic analogues N-acetylsolasodine (4) and N,O-diacetylsolasodine (5) were found to be inactive. Compounds 2 and 3 are new natural products.",

author = "Kim, \{Youn C.\} and Che, \{Qing Ming\} and Gunatilaka, \{A. A.Leslie\} and Kingston, \{David G.I.\}",

year = "1996",

month = mar,

doi = "10.1021/np960125a",

language = "English (US)",

volume = "59",

pages = "283--285",

journal = "Journal Of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

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T1 - Bioactive steroidal alkaloids from Solanum umbelliferum

AU - Kim, Youn C.

AU - Che, Qing Ming

AU - Gunatilaka, A. A.Leslie

AU - Kingston, David G.I.

PY - 1996/3

Y1 - 1996/3

N2 - Bioassay-directed fractionation of the MeOH extract of Solanum umbelliferum afforded solasodine (1), O-acetylsolasodine (2), and solasodine 3-O-β-D-glucopyranoside (3). Alkaloids 1 and 2 exhibited significant activity toward DNA repair-deficient yeast mutants, whereas 3 and the synthetic analogues N-acetylsolasodine (4) and N,O-diacetylsolasodine (5) were found to be inactive. Compounds 2 and 3 are new natural products.

AB - Bioassay-directed fractionation of the MeOH extract of Solanum umbelliferum afforded solasodine (1), O-acetylsolasodine (2), and solasodine 3-O-β-D-glucopyranoside (3). Alkaloids 1 and 2 exhibited significant activity toward DNA repair-deficient yeast mutants, whereas 3 and the synthetic analogues N-acetylsolasodine (4) and N,O-diacetylsolasodine (5) were found to be inactive. Compounds 2 and 3 are new natural products.

UR - https://www.scopus.com/pages/publications/0029881578

UR - https://www.scopus.com/pages/publications/0029881578#tab=citedBy

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JO - Journal Of Natural Products

JF - Journal Of Natural Products

IS - 3

ER -

Bioactive steroidal alkaloids from Solanum umbelliferum

Abstract

ASJC Scopus subject areas

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