Bioactive steroidal alkaloids from Solanum umbelliferum

Youn C. Kim, Qing Ming Che, A. A.Leslie Gunatilaka, David G.I. Kingston

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Bioassay-directed fractionation of the MeOH extract of Solanum umbelliferum afforded solasodine (1), O-acetylsolasodine (2), and solasodine 3-O-β-D-glucopyranoside (3). Alkaloids 1 and 2 exhibited significant activity toward DNA repair-deficient yeast mutants, whereas 3 and the synthetic analogues N-acetylsolasodine (4) and N,O-diacetylsolasodine (5) were found to be inactive. Compounds 2 and 3 are new natural products.

Original languageEnglish (US)
Pages (from-to)283-285
Number of pages3
JournalJournal Of Natural Products
Issue number3
StatePublished - Mar 1996

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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