Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid

Fabiola N. Velazquez; Maria Hernandez-Corbacho; Magali Trayssac; Jeffrey L. Stith; Joseph Bonica; Bernandie Jean; Michael J. Pulkoski-Gross; Brittany L. Carroll; Mohamed F. Salama; Yusuf A. Hannun; Ashley J. Snider

doi:10.1016/j.cellsig.2020.109875

Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid

Fabiola N. Velazquez, Maria Hernandez-Corbacho, Magali Trayssac, Jeffrey L. Stith, Joseph Bonica, Bernandie Jean, Michael J. Pulkoski-Gross, Brittany L. Carroll, Mohamed F. Salama, Yusuf A. Hannun, Ashley J. Snider

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Sphingolipids and their synthetic enzymes have emerged as critical mediators in numerous diseases including inflammation, aging, and cancer. One enzyme in particular, sphingosine kinase (SK) and its product sphingosine-1-phosphate (S1P), has been extensively implicated in these processes. SK catalyzes the phosphorylation of sphingosine to S1P and exists as two isoforms, SK1 and SK2. In this review, we will discuss the contributions from the laboratory of Dr. Lina M. Obeid that have defined the roles for several bioactive sphingolipids in signaling and disease with an emphasis on her work defining SK1 in cellular fates and pathobiologies including proliferation, senescence, apoptosis, and inflammation.

Original language	English (US)
Article number	109875
Journal	Cellular Signalling
Volume	79
DOIs	https://doi.org/10.1016/j.cellsig.2020.109875
State	Published - Mar 2021
Externally published	Yes

ASJC Scopus subject areas

Cell Biology

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title = "Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid",

abstract = "Sphingolipids and their synthetic enzymes have emerged as critical mediators in numerous diseases including inflammation, aging, and cancer. One enzyme in particular, sphingosine kinase (SK) and its product sphingosine-1-phosphate (S1P), has been extensively implicated in these processes. SK catalyzes the phosphorylation of sphingosine to S1P and exists as two isoforms, SK1 and SK2. In this review, we will discuss the contributions from the laboratory of Dr. Lina M. Obeid that have defined the roles for several bioactive sphingolipids in signaling and disease with an emphasis on her work defining SK1 in cellular fates and pathobiologies including proliferation, senescence, apoptosis, and inflammation.",

author = "Velazquez, \{Fabiola N.\} and Maria Hernandez-Corbacho and Magali Trayssac and Stith, \{Jeffrey L.\} and Joseph Bonica and Bernandie Jean and Pulkoski-Gross, \{Michael J.\} and Carroll, \{Brittany L.\} and Salama, \{Mohamed F.\} and Hannun, \{Yusuf A.\} and Snider, \{Ashley J.\}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2021",

month = mar,

doi = "10.1016/j.cellsig.2020.109875",

language = "English (US)",

volume = "79",

journal = "Cellular Signalling",

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AU - Velazquez, Fabiola N.

AU - Hernandez-Corbacho, Maria

AU - Trayssac, Magali

AU - Stith, Jeffrey L.

AU - Bonica, Joseph

AU - Jean, Bernandie

AU - Pulkoski-Gross, Michael J.

AU - Carroll, Brittany L.

AU - Salama, Mohamed F.

AU - Hannun, Yusuf A.

AU - Snider, Ashley J.

PY - 2021/3

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AB - Sphingolipids and their synthetic enzymes have emerged as critical mediators in numerous diseases including inflammation, aging, and cancer. One enzyme in particular, sphingosine kinase (SK) and its product sphingosine-1-phosphate (S1P), has been extensively implicated in these processes. SK catalyzes the phosphorylation of sphingosine to S1P and exists as two isoforms, SK1 and SK2. In this review, we will discuss the contributions from the laboratory of Dr. Lina M. Obeid that have defined the roles for several bioactive sphingolipids in signaling and disease with an emphasis on her work defining SK1 in cellular fates and pathobiologies including proliferation, senescence, apoptosis, and inflammation.

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Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid

Abstract

ASJC Scopus subject areas

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