Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid

Fabiola N. Velazquez, Maria Hernandez-Corbacho, Magali Trayssac, Jeffrey L. Stith, Joseph Bonica, Bernandie Jean, Michael J. Pulkoski-Gross, Brittany L. Carroll, Mohamed F. Salama, Yusuf A. Hannun, Ashley J. Snider

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Sphingolipids and their synthetic enzymes have emerged as critical mediators in numerous diseases including inflammation, aging, and cancer. One enzyme in particular, sphingosine kinase (SK) and its product sphingosine-1-phosphate (S1P), has been extensively implicated in these processes. SK catalyzes the phosphorylation of sphingosine to S1P and exists as two isoforms, SK1 and SK2. In this review, we will discuss the contributions from the laboratory of Dr. Lina M. Obeid that have defined the roles for several bioactive sphingolipids in signaling and disease with an emphasis on her work defining SK1 in cellular fates and pathobiologies including proliferation, senescence, apoptosis, and inflammation.

Original languageEnglish (US)
Article number109875
JournalCellular Signalling
Volume79
DOIs
StatePublished - Mar 2021
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

Fingerprint

Dive into the research topics of 'Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid'. Together they form a unique fingerprint.

Cite this