TY - JOUR
T1 - Bioactive sphingolipids
T2 - Advancements and contributions from the laboratory of Dr. Lina M. Obeid
AU - Velazquez, Fabiola N.
AU - Hernandez-Corbacho, Maria
AU - Trayssac, Magali
AU - Stith, Jeffrey L.
AU - Bonica, Joseph
AU - Jean, Bernandie
AU - Pulkoski-Gross, Michael J.
AU - Carroll, Brittany L.
AU - Salama, Mohamed F.
AU - Hannun, Yusuf A.
AU - Snider, Ashley J.
N1 - Funding Information:
The authors would like to thank the many students, trainees, and colleagues who have worked in or have collaborated with the Obeid lab over the years (Table S1). Dr. Obeid trained 18 graduate students in her laboratory (1 M.S. student, 10 Ph.D. students, and 7 M.D./Ph.D. students) served on the thesis committees for 34 additional graduate students, mentored 22 postdoctoral scientists, 4 visiting scientists on sabbatical, 25 junior faculty, and numerous undergraduate and medical students. This work was supported by multiple NIH grants and assistance programs spanning the career of Dr. Obeid.
Publisher Copyright:
© 2020 The Authors
PY - 2021/3
Y1 - 2021/3
N2 - Sphingolipids and their synthetic enzymes have emerged as critical mediators in numerous diseases including inflammation, aging, and cancer. One enzyme in particular, sphingosine kinase (SK) and its product sphingosine-1-phosphate (S1P), has been extensively implicated in these processes. SK catalyzes the phosphorylation of sphingosine to S1P and exists as two isoforms, SK1 and SK2. In this review, we will discuss the contributions from the laboratory of Dr. Lina M. Obeid that have defined the roles for several bioactive sphingolipids in signaling and disease with an emphasis on her work defining SK1 in cellular fates and pathobiologies including proliferation, senescence, apoptosis, and inflammation.
AB - Sphingolipids and their synthetic enzymes have emerged as critical mediators in numerous diseases including inflammation, aging, and cancer. One enzyme in particular, sphingosine kinase (SK) and its product sphingosine-1-phosphate (S1P), has been extensively implicated in these processes. SK catalyzes the phosphorylation of sphingosine to S1P and exists as two isoforms, SK1 and SK2. In this review, we will discuss the contributions from the laboratory of Dr. Lina M. Obeid that have defined the roles for several bioactive sphingolipids in signaling and disease with an emphasis on her work defining SK1 in cellular fates and pathobiologies including proliferation, senescence, apoptosis, and inflammation.
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U2 - 10.1016/j.cellsig.2020.109875
DO - 10.1016/j.cellsig.2020.109875
M3 - Article
C2 - 33290840
AN - SCOPUS:85097908611
VL - 79
JO - Cellular Signalling
JF - Cellular Signalling
SN - 0898-6568
M1 - 109875
ER -