Bioactive guanidine alkaloids from pterogyne nitens

Vanderlan Da S. Bolzani; A. A.Leslie Gunatilaka; David G.I. Kingston

doi:10.1021/np50125a006

Bioactive guanidine alkaloids from pterogyne nitens

Vanderlan Da S. Bolzani, A. A.Leslie Gunatilaka, David G.I. Kingston

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Bioactivity-guided fractionation of a methanolic CHC1₃ extract of the leaves of Pterogyne nitens afforded the known guanidine alkaloid pterogynidine [2] and three new guanidine alkaloids, nitensidines A [3], B [4], and C [5], all of which exhibited selective activity towards the DNA repair-deficient yeast mutant RS 321 (IC₁₂=93-20.0 μg/ml); 3,4, and 5 were moderately cytotoxic to CHO Aux B₁ cells (IC₅₀=8.5-13.0 μg/ml).

Original language	English (US)
Pages (from-to)	1683-1688
Number of pages	6
Journal	Journal Of Natural Products
Volume	58
Issue number	11
DOIs	https://doi.org/10.1021/np50125a006
State	Published - Nov 1 1995
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Bioactive guanidine alkaloids from pterogyne nitens",

abstract = "Bioactivity-guided fractionation of a methanolic CHC13 extract of the leaves of Pterogyne nitens afforded the known guanidine alkaloid pterogynidine [2] and three new guanidine alkaloids, nitensidines A [3], B [4], and C [5], all of which exhibited selective activity towards the DNA repair-deficient yeast mutant RS 321 (IC12=93-20.0 μg/ml); 3,4, and 5 were moderately cytotoxic to CHO Aux B1 cells (IC50=8.5-13.0 μg/ml).",

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AU - Bolzani, Vanderlan Da S.

AU - Gunatilaka, A. A.Leslie

AU - Kingston, David G.I.

PY - 1995/11/1

Y1 - 1995/11/1

N2 - Bioactivity-guided fractionation of a methanolic CHC13 extract of the leaves of Pterogyne nitens afforded the known guanidine alkaloid pterogynidine [2] and three new guanidine alkaloids, nitensidines A [3], B [4], and C [5], all of which exhibited selective activity towards the DNA repair-deficient yeast mutant RS 321 (IC12=93-20.0 μg/ml); 3,4, and 5 were moderately cytotoxic to CHO Aux B1 cells (IC50=8.5-13.0 μg/ml).

AB - Bioactivity-guided fractionation of a methanolic CHC13 extract of the leaves of Pterogyne nitens afforded the known guanidine alkaloid pterogynidine [2] and three new guanidine alkaloids, nitensidines A [3], B [4], and C [5], all of which exhibited selective activity towards the DNA repair-deficient yeast mutant RS 321 (IC12=93-20.0 μg/ml); 3,4, and 5 were moderately cytotoxic to CHO Aux B1 cells (IC50=8.5-13.0 μg/ml).

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JF - Journal Of Natural Products

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ER -

Bioactive guanidine alkaloids from pterogyne nitens

Abstract

ASJC Scopus subject areas

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