Abstract
Bioassay-directed fractionation of the MeCOEt extract of Crescentia cujete (Bignonaceae) resulted in the isolation of (2S,3S)-3-hydroxy-5,6-dimethoxydehydroiso-α-lapachone [1], (2R)-5,6-dimethoxydehydroiso-α-lapachone [2], (2R)-5-methoxydehydroiso-α-lapachone [3], 2-(l-hydroxyethyl)naphtho[2,3-b]furan-4,9-dione [4], 5-hydroxy-2-(l-hydroxyethyl)naphtho[2,3-b]furan-4,9-dione[5], 2-isopropenylnaphtho[2,3-b]furan-4, 9-dione [6], and 5-hydroxydehydroiso-α-lapachone [7]. Compounds 1–3 are new, and all compounds are bioactive, showing selective activity towards DNA-repair-deficient yeast mutants. The isolation, structure elucidation, and biological activities of these compounds are reported.
Original language | English (US) |
---|---|
Pages (from-to) | 1500-1505 |
Number of pages | 6 |
Journal | Journal Of Natural Products |
Volume | 56 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1993 |
Externally published | Yes |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry