Bioactive flavone dimers from Ouratea multiflora (Ochnaceae)

Carlos Alberto Carbonezi; Lidilhone Hamerski; A. A.Leslie Gunatilaka; Alberto Cavalheiro; Ian Castro-Gamboa; Dulce Helena Siqueira Silva; Maysa Furlan; Maria Claudia Marx Young; Marcia Nasser Lopes; Vanderlan Da Silva Bolzani

doi:10.1590/S0102-695X2007000300003

Bioactive flavone dimers from Ouratea multiflora (Ochnaceae)

Carlos Alberto Carbonezi
, Lidilhone Hamerski
, A. A.Leslie Gunatilaka
, Alberto Cavalheiro
, Ian Castro-Gamboa
, Dulce Helena Siqueira Silva
, Maysa Furlan
, Maria Claudia Marx Young
, Marcia Nasser Lopes
, Vanderlan Da Silva Bolzani

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Chromatographic fractionation of the organic extract from leaves of Ouratea multiflora afforded the flavone dimers heveaflavone, amentoflavone-7′, 4‴-dimethyl eter, podocarpusflavone-A and amentoflavone. Their structures were elucidated from spectral data, including 2D-NMR experiments of the natural substances. Biological activities of all isolates were evaluated, using antimicrobial assay against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, cytotoxicity assay against mouse lymphoma (L5178) and KB cell lines, TLC screening for acetylcholinesterase inhibitors and antioxidant activity measured by DPPH test.

Original language	English (US)
Pages (from-to)	319-324
Number of pages	6
Journal	Revista Brasileira de Farmacognosia
Volume	17
Issue number	3
DOIs	https://doi.org/10.1590/S0102-695X2007000300003
State	Published - 2007

Keywords

Antibacterial activity
Biflavonoids
Ochnaceae
Ouratea multiflora

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)

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10.1590/S0102-695X2007000300003

Cite this

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title = "Bioactive flavone dimers from Ouratea multiflora (Ochnaceae)",

abstract = "Chromatographic fractionation of the organic extract from leaves of Ouratea multiflora afforded the flavone dimers heveaflavone, amentoflavone-7′, 4‴-dimethyl eter, podocarpusflavone-A and amentoflavone. Their structures were elucidated from spectral data, including 2D-NMR experiments of the natural substances. Biological activities of all isolates were evaluated, using antimicrobial assay against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, cytotoxicity assay against mouse lymphoma (L5178) and KB cell lines, TLC screening for acetylcholinesterase inhibitors and antioxidant activity measured by DPPH test.",

keywords = "Antibacterial activity, Biflavonoids, Ochnaceae, Ouratea multiflora",

author = "Carbonezi, \{Carlos Alberto\} and Lidilhone Hamerski and Gunatilaka, \{A. A.Leslie\} and Alberto Cavalheiro and Ian Castro-Gamboa and Silva, \{Dulce Helena Siqueira\} and Maysa Furlan and Young, \{Maria Claudia Marx\} and Lopes, \{Marcia Nasser\} and \{Da Silva Bolzani\}, Vanderlan",

year = "2007",

doi = "10.1590/S0102-695X2007000300003",

language = "English (US)",

volume = "17",

pages = "319--324",

journal = "Revista Brasileira de Farmacognosia",

issn = "0102-695X",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "3",

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TY - JOUR

T1 - Bioactive flavone dimers from Ouratea multiflora (Ochnaceae)

AU - Carbonezi, Carlos Alberto

AU - Hamerski, Lidilhone

AU - Gunatilaka, A. A.Leslie

AU - Cavalheiro, Alberto

AU - Castro-Gamboa, Ian

AU - Silva, Dulce Helena Siqueira

AU - Furlan, Maysa

AU - Young, Maria Claudia Marx

AU - Lopes, Marcia Nasser

AU - Da Silva Bolzani, Vanderlan

PY - 2007

Y1 - 2007

N2 - Chromatographic fractionation of the organic extract from leaves of Ouratea multiflora afforded the flavone dimers heveaflavone, amentoflavone-7′, 4‴-dimethyl eter, podocarpusflavone-A and amentoflavone. Their structures were elucidated from spectral data, including 2D-NMR experiments of the natural substances. Biological activities of all isolates were evaluated, using antimicrobial assay against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, cytotoxicity assay against mouse lymphoma (L5178) and KB cell lines, TLC screening for acetylcholinesterase inhibitors and antioxidant activity measured by DPPH test.

AB - Chromatographic fractionation of the organic extract from leaves of Ouratea multiflora afforded the flavone dimers heveaflavone, amentoflavone-7′, 4‴-dimethyl eter, podocarpusflavone-A and amentoflavone. Their structures were elucidated from spectral data, including 2D-NMR experiments of the natural substances. Biological activities of all isolates were evaluated, using antimicrobial assay against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, cytotoxicity assay against mouse lymphoma (L5178) and KB cell lines, TLC screening for acetylcholinesterase inhibitors and antioxidant activity measured by DPPH test.

KW - Antibacterial activity

KW - Biflavonoids

KW - Ochnaceae

KW - Ouratea multiflora

UR - https://www.scopus.com/pages/publications/35248895377

UR - https://www.scopus.com/pages/publications/35248895377#tab=citedBy

U2 - 10.1590/S0102-695X2007000300003

DO - 10.1590/S0102-695X2007000300003

M3 - Article

AN - SCOPUS:35248895377

SN - 0102-695X

VL - 17

SP - 319

EP - 324

JO - Revista Brasileira de Farmacognosia

JF - Revista Brasileira de Farmacognosia

IS - 3

ER -

Bioactive flavone dimers from Ouratea multiflora (Ochnaceae)

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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