TY - JOUR
T1 - Bioactive flavone dimers from Ouratea multiflora (Ochnaceae)
AU - Carbonezi, Carlos Alberto
AU - Hamerski, Lidilhone
AU - Gunatilaka, A. A.Leslie
AU - Cavalheiro, Alberto
AU - Castro-Gamboa, Ian
AU - Silva, Dulce Helena Siqueira
AU - Furlan, Maysa
AU - Young, Maria Claudia Marx
AU - Lopes, Marcia Nasser
AU - Da Silva Bolzani, Vanderlan
PY - 2007
Y1 - 2007
N2 - Chromatographic fractionation of the organic extract from leaves of Ouratea multiflora afforded the flavone dimers heveaflavone, amentoflavone-7′, 4‴-dimethyl eter, podocarpusflavone-A and amentoflavone. Their structures were elucidated from spectral data, including 2D-NMR experiments of the natural substances. Biological activities of all isolates were evaluated, using antimicrobial assay against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, cytotoxicity assay against mouse lymphoma (L5178) and KB cell lines, TLC screening for acetylcholinesterase inhibitors and antioxidant activity measured by DPPH test.
AB - Chromatographic fractionation of the organic extract from leaves of Ouratea multiflora afforded the flavone dimers heveaflavone, amentoflavone-7′, 4‴-dimethyl eter, podocarpusflavone-A and amentoflavone. Their structures were elucidated from spectral data, including 2D-NMR experiments of the natural substances. Biological activities of all isolates were evaluated, using antimicrobial assay against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, cytotoxicity assay against mouse lymphoma (L5178) and KB cell lines, TLC screening for acetylcholinesterase inhibitors and antioxidant activity measured by DPPH test.
KW - Antibacterial activity
KW - Biflavonoids
KW - Ochnaceae
KW - Ouratea multiflora
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U2 - 10.1590/S0102-695X2007000300003
DO - 10.1590/S0102-695X2007000300003
M3 - Article
AN - SCOPUS:35248895377
SN - 0102-695X
VL - 17
SP - 319
EP - 324
JO - Revista Brasileira de Farmacognosia
JF - Revista Brasileira de Farmacognosia
IS - 3
ER -