Bioactive ergost-5-ene-3β,7α-diol derivatives from pseudobersama mossambicensis

A. A.Leslie Gunatilaka; Gamini Samaranayake; David G.I. Kingston; Glenn Hoffmann; Randall K. Johnson

doi:10.1021/np50089a014

Bioactive ergost-5-ene-3β,7α-diol derivatives from pseudobersama mossambicensis

A. A.Leslie Gunatilaka, Gamini Samaranayake, David G.I. Kingston, Glenn Hoffmann, Randall K. Johnson

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Bioactivity-directed fractionation of the methyl ethyl ketone extract of Pseudobersama mossambicensis resulted in the isolation of ergosta-5,24(28)-diene-3β,7α-diol {1}, 24,28-epoxyergost-5-ene-3β,7α-diol {2}, and ergost-5-ene-3β,7α,24,28-tetraol {3}. All three sterols showed selective activity towards DNA repair-deficient yeast mutants. The sterol 1 also showed cytotoxicity towards wild-type P-388 murine leukemia cells. The isolation, structural elucidation, and biological activities of these sterols are reported. The sterol 3 is most probably an artifact formed from 2 during the isolation process.

Original language	English (US)
Pages (from-to)	1648-1654
Number of pages	7
Journal	Journal Of Natural Products
Volume	55
Issue number	11
DOIs	https://doi.org/10.1021/np50089a014
State	Published - Nov 1 1992
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Bioactive ergost-5-ene-3β,7α-diol derivatives from pseudobersama mossambicensis",

abstract = "Bioactivity-directed fractionation of the methyl ethyl ketone extract of Pseudobersama mossambicensis resulted in the isolation of ergosta-5,24(28)-diene-3β,7α-diol {1}, 24,28-epoxyergost-5-ene-3β,7α-diol {2}, and ergost-5-ene-3β,7α,24,28-tetraol {3}. All three sterols showed selective activity towards DNA repair-deficient yeast mutants. The sterol 1 also showed cytotoxicity towards wild-type P-388 murine leukemia cells. The isolation, structural elucidation, and biological activities of these sterols are reported. The sterol 3 is most probably an artifact formed from 2 during the isolation process.",

author = "Gunatilaka, {A. A.Leslie} and Gamini Samaranayake and Kingston, {David G.I.} and Glenn Hoffmann and Johnson, {Randall K.}",

year = "1992",

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T1 - Bioactive ergost-5-ene-3β,7α-diol derivatives from pseudobersama mossambicensis

AU - Gunatilaka, A. A.Leslie

AU - Samaranayake, Gamini

AU - Kingston, David G.I.

AU - Hoffmann, Glenn

AU - Johnson, Randall K.

PY - 1992/11/1

Y1 - 1992/11/1

N2 - Bioactivity-directed fractionation of the methyl ethyl ketone extract of Pseudobersama mossambicensis resulted in the isolation of ergosta-5,24(28)-diene-3β,7α-diol {1}, 24,28-epoxyergost-5-ene-3β,7α-diol {2}, and ergost-5-ene-3β,7α,24,28-tetraol {3}. All three sterols showed selective activity towards DNA repair-deficient yeast mutants. The sterol 1 also showed cytotoxicity towards wild-type P-388 murine leukemia cells. The isolation, structural elucidation, and biological activities of these sterols are reported. The sterol 3 is most probably an artifact formed from 2 during the isolation process.

AB - Bioactivity-directed fractionation of the methyl ethyl ketone extract of Pseudobersama mossambicensis resulted in the isolation of ergosta-5,24(28)-diene-3β,7α-diol {1}, 24,28-epoxyergost-5-ene-3β,7α-diol {2}, and ergost-5-ene-3β,7α,24,28-tetraol {3}. All three sterols showed selective activity towards DNA repair-deficient yeast mutants. The sterol 1 also showed cytotoxicity towards wild-type P-388 murine leukemia cells. The isolation, structural elucidation, and biological activities of these sterols are reported. The sterol 3 is most probably an artifact formed from 2 during the isolation process.

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Bioactive ergost-5-ene-3β,7α-diol derivatives from pseudobersama mossambicensis

Abstract

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