Abstract
Bioassay-directed fractionation of the methyl ethyl ketone extract of Chiloscyphus rivularis yielded five new sesquiterpenes, 12- hydroxychiloscyphone (2), chiloscypha-2,7-dione (3), 12-hydroxychiloscypha- 2,7-dione (4), chiloscypha-2,7,9-trione (5), and rivulalactone (6) in addition to the known sesquiterpenes, 4-hydroxyoppositan-7-one (7), chiloscyphone (1), and isointermedeol (8). The structure and stereochemistry of rivulalactone, a novel trinorsesquiterpene, was confirmed by its synthesis starting from 1. Compound 2 showed selective bioactivity in our yeast-based DNA-damaging assay and cytotoxicity to human lung carcinoma cells.
Original language | English (US) |
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Pages (from-to) | 1281-1286 |
Number of pages | 6 |
Journal | Journal Of Natural Products |
Volume | 60 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1997 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry