Bioactive and other piperidine alkaloids from Cassia leptophylla

Vanderlan da S. Bolzani; A. A. Leslie Gunatilaka; David G.I. Kingston

doi:10.1016/0040-4020(95)00254-6

Bioactive and other piperidine alkaloids from Cassia leptophylla

Vanderlan da S. Bolzani
, A. A. Leslie Gunatilaka
, David G.I. Kingston

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Four new piperidine alkaloids, leptophyllin A (4), 3-acetylleptophyllin A (5), leptophyllin B (8), and (-)-spectaline (1), and 3 known piperidine alkaloids, (-)-spectalinine (2), canavaline (3), and iso-6-canavaline (7), were isolated by a bioassay-guided fractionation of a leaf extract of Cassia leptophylla. The alkaloids 1-3 were active in a mechanism-based DNA-modifying yeast assay and 2 was moderately active in Vero monkey and Chinese hamster ovary cell cytotoxicity assays.

Original language	English (US)
Pages (from-to)	5929-5934
Number of pages	6
Journal	Tetrahedron
Volume	51
Issue number	21
DOIs	https://doi.org/10.1016/0040-4020(95)00254-6
State	Published - May 22 1995
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Bioactive and other piperidine alkaloids from Cassia leptophylla",

abstract = "Four new piperidine alkaloids, leptophyllin A (4), 3-acetylleptophyllin A (5), leptophyllin B (8), and (-)-spectaline (1), and 3 known piperidine alkaloids, (-)-spectalinine (2), canavaline (3), and iso-6-canavaline (7), were isolated by a bioassay-guided fractionation of a leaf extract of Cassia leptophylla. The alkaloids 1-3 were active in a mechanism-based DNA-modifying yeast assay and 2 was moderately active in Vero monkey and Chinese hamster ovary cell cytotoxicity assays.",

author = "Bolzani, \{Vanderlan da S.\} and \{Leslie Gunatilaka\}, \{A. A.\} and Kingston, \{David G.I.\}",

year = "1995",

month = may,

day = "22",

doi = "10.1016/0040-4020(95)00254-6",

language = "English (US)",

volume = "51",

pages = "5929--5934",

journal = "Tetrahedron",

issn = "0040-4020",

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number = "21",

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TY - JOUR

T1 - Bioactive and other piperidine alkaloids from Cassia leptophylla

AU - Bolzani, Vanderlan da S.

AU - Leslie Gunatilaka, A. A.

AU - Kingston, David G.I.

PY - 1995/5/22

Y1 - 1995/5/22

N2 - Four new piperidine alkaloids, leptophyllin A (4), 3-acetylleptophyllin A (5), leptophyllin B (8), and (-)-spectaline (1), and 3 known piperidine alkaloids, (-)-spectalinine (2), canavaline (3), and iso-6-canavaline (7), were isolated by a bioassay-guided fractionation of a leaf extract of Cassia leptophylla. The alkaloids 1-3 were active in a mechanism-based DNA-modifying yeast assay and 2 was moderately active in Vero monkey and Chinese hamster ovary cell cytotoxicity assays.

AB - Four new piperidine alkaloids, leptophyllin A (4), 3-acetylleptophyllin A (5), leptophyllin B (8), and (-)-spectaline (1), and 3 known piperidine alkaloids, (-)-spectalinine (2), canavaline (3), and iso-6-canavaline (7), were isolated by a bioassay-guided fractionation of a leaf extract of Cassia leptophylla. The alkaloids 1-3 were active in a mechanism-based DNA-modifying yeast assay and 2 was moderately active in Vero monkey and Chinese hamster ovary cell cytotoxicity assays.

UR - https://www.scopus.com/pages/publications/0029042112

UR - https://www.scopus.com/pages/publications/0029042112#tab=citedBy

U2 - 10.1016/0040-4020(95)00254-6

DO - 10.1016/0040-4020(95)00254-6

M3 - Article

AN - SCOPUS:0029042112

SN - 0040-4020

VL - 51

SP - 5929

EP - 5934

JO - Tetrahedron

JF - Tetrahedron

IS - 21

ER -

Bioactive and other piperidine alkaloids from Cassia leptophylla

Abstract

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