TY - JOUR
T1 - Bioactive and other piperidine alkaloids from Cassia leptophylla
AU - Bolzani, Vanderlan da S.
AU - Leslie Gunatilaka, A. A.
AU - Kingston, David G.I.
PY - 1995/5/22
Y1 - 1995/5/22
N2 - Four new piperidine alkaloids, leptophyllin A (4), 3-acetylleptophyllin A (5), leptophyllin B (8), and (-)-spectaline (1), and 3 known piperidine alkaloids, (-)-spectalinine (2), canavaline (3), and iso-6-canavaline (7), were isolated by a bioassay-guided fractionation of a leaf extract of Cassia leptophylla. The alkaloids 1-3 were active in a mechanism-based DNA-modifying yeast assay and 2 was moderately active in Vero monkey and Chinese hamster ovary cell cytotoxicity assays.
AB - Four new piperidine alkaloids, leptophyllin A (4), 3-acetylleptophyllin A (5), leptophyllin B (8), and (-)-spectaline (1), and 3 known piperidine alkaloids, (-)-spectalinine (2), canavaline (3), and iso-6-canavaline (7), were isolated by a bioassay-guided fractionation of a leaf extract of Cassia leptophylla. The alkaloids 1-3 were active in a mechanism-based DNA-modifying yeast assay and 2 was moderately active in Vero monkey and Chinese hamster ovary cell cytotoxicity assays.
UR - http://www.scopus.com/inward/record.url?scp=0029042112&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029042112&partnerID=8YFLogxK
U2 - 10.1016/0040-4020(95)00254-6
DO - 10.1016/0040-4020(95)00254-6
M3 - Article
AN - SCOPUS:0029042112
SN - 0040-4020
VL - 51
SP - 5929
EP - 5934
JO - Tetrahedron
JF - Tetrahedron
IS - 21
ER -