Bioactive and other piperidine alkaloids from Cassia leptophylla

Vanderlan da S. Bolzani, A. A. Leslie Gunatilaka, David G.I. Kingston

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


Four new piperidine alkaloids, leptophyllin A (4), 3-acetylleptophyllin A (5), leptophyllin B (8), and (-)-spectaline (1), and 3 known piperidine alkaloids, (-)-spectalinine (2), canavaline (3), and iso-6-canavaline (7), were isolated by a bioassay-guided fractionation of a leaf extract of Cassia leptophylla. The alkaloids 1-3 were active in a mechanism-based DNA-modifying yeast assay and 2 was moderately active in Vero monkey and Chinese hamster ovary cell cytotoxicity assays.

Original languageEnglish (US)
Pages (from-to)5929-5934
Number of pages6
Issue number21
StatePublished - May 22 1995

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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