Bile acid activation of the gadd153 promoter and of p53-independent apoptosis: Relevance to colon cancer

Zhi Ying Zheng; Harris Bernstein; Carol Bernstein; Claire M. Payne; Jesse D. Martinez; Eugene W. Gerner

Bile acid activation of the gadd153 promoter and of p53-independent apoptosis: Relevance to colon cancer

Zhi Ying Zheng, Harris Bernstein, Carol Bernstein, Claire M. Payne, Jesse D. Martinez, Eugene W. Gerner

Cellular and Molecular Medicine

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Bile acids are strongly implicated in the etiology of colon cancer. Bile acids also induce apoptosis, and this action may be a key to understanding their role in colon cancer. However the mechanism of bile acid induction of apoptosis is not known. We present evidence of bile acid activation of the gadd153 promoter (a promoter activated by DNA damaging agents). We also show that bile acid induction of apoptosis is p53-independent. In addition, bile salts were found to induce blebbing preceding the actual morphological onset of apoptosis, which indicates early cytoskeletal alterations.

Original language	English (US)
Pages (from-to)	407-414
Number of pages	8
Journal	Cell Death and Differentiation
Volume	3
Issue number	4
State	Published - 1996

Keywords

Apoptosis
Bile salts
Colon cancer
Cytoskeleton
gadd153
p53

ASJC Scopus subject areas

Molecular Biology
Cell Biology

Cite this

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title = "Bile acid activation of the gadd153 promoter and of p53-independent apoptosis: Relevance to colon cancer",

abstract = "Bile acids are strongly implicated in the etiology of colon cancer. Bile acids also induce apoptosis, and this action may be a key to understanding their role in colon cancer. However the mechanism of bile acid induction of apoptosis is not known. We present evidence of bile acid activation of the gadd153 promoter (a promoter activated by DNA damaging agents). We also show that bile acid induction of apoptosis is p53-independent. In addition, bile salts were found to induce blebbing preceding the actual morphological onset of apoptosis, which indicates early cytoskeletal alterations.",

keywords = "Apoptosis, Bile salts, Colon cancer, Cytoskeleton, gadd153, p53",

author = "Zheng, {Zhi Ying} and Harris Bernstein and Carol Bernstein and Payne, {Claire M.} and Martinez, {Jesse D.} and Gerner, {Eugene W.}",

year = "1996",

language = "English (US)",

volume = "3",

pages = "407--414",

journal = "Cell Death and Differentiation",

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T1 - Bile acid activation of the gadd153 promoter and of p53-independent apoptosis

T2 - Relevance to colon cancer

AU - Zheng, Zhi Ying

AU - Bernstein, Harris

AU - Bernstein, Carol

AU - Payne, Claire M.

AU - Martinez, Jesse D.

AU - Gerner, Eugene W.

PY - 1996

Y1 - 1996

N2 - Bile acids are strongly implicated in the etiology of colon cancer. Bile acids also induce apoptosis, and this action may be a key to understanding their role in colon cancer. However the mechanism of bile acid induction of apoptosis is not known. We present evidence of bile acid activation of the gadd153 promoter (a promoter activated by DNA damaging agents). We also show that bile acid induction of apoptosis is p53-independent. In addition, bile salts were found to induce blebbing preceding the actual morphological onset of apoptosis, which indicates early cytoskeletal alterations.

AB - Bile acids are strongly implicated in the etiology of colon cancer. Bile acids also induce apoptosis, and this action may be a key to understanding their role in colon cancer. However the mechanism of bile acid induction of apoptosis is not known. We present evidence of bile acid activation of the gadd153 promoter (a promoter activated by DNA damaging agents). We also show that bile acid induction of apoptosis is p53-independent. In addition, bile salts were found to induce blebbing preceding the actual morphological onset of apoptosis, which indicates early cytoskeletal alterations.

KW - Apoptosis

KW - Bile salts

KW - Colon cancer

KW - Cytoskeleton

KW - gadd153

KW - p53

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AN - SCOPUS:0029836555

SN - 1350-9047

VL - 3

SP - 407

EP - 414

JO - Cell Death and Differentiation

JF - Cell Death and Differentiation

IS - 4

ER -

Bile acid activation of the gadd153 promoter and of p53-independent apoptosis: Relevance to colon cancer

Abstract

Keywords

ASJC Scopus subject areas

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