Bilateral hippocampal volume predicts verbal memory function in temporal lobe epilepsy

Sheryl L. Reminger, Alfred W. Kaszniak, David M. Labiner, Lindsey D. Littrell, Brian T. David, Lee Ryan, Anne M. Herring, Kris L. Kaemingk

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


The present study used quantitative volume estimates of the hippocampus based on structural magnetic resonance imaging (MRI) to predict memory performance of individuals with epilepsy of temporal lobe origin (TLE). Twenty individuals with TLE completed standardized neuropsychological tests and a quality of life inventory, and participated in a brain MRI protocol designed to obtain high-resolution images of the hippocampus. The combined volume of the left and right hippocampi was found to be the best predictor of objective verbal memory performance. This finding is consistent with the functional adequacy model of hippocampal function. In contrast, the asymmetry between right and left hippocampal volume was the best predictor of subjective ratings of cognitive functioning, which is consistent with the functional reserve model. The collective and complementary functions of the left and right hippocampi merit further exploration in prospective studies of memory function and TLE.

Original languageEnglish (US)
Pages (from-to)687-695
Number of pages9
JournalEpilepsy and Behavior
Issue number5
StatePublished - Oct 2004


  • Hippocampus
  • Magnetic resonance imaging
  • Memory
  • Neuropsychology
  • Quality of life
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience


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