Bilateral hippocampal volume predicts verbal memory function in temporal lobe epilepsy

Sheryl L. Reminger; Alfred W Kaszniak; David M. Labiner; Lindsey D. Littrell; Brian T. David; Lee Ryan; Anne M. Herring; Kris L. Kaemingk

doi:10.1016/j.yebeh.2004.06.006

Bilateral hippocampal volume predicts verbal memory function in temporal lobe epilepsy

Sheryl L. Reminger, Alfred W Kaszniak, David M. Labiner, Lindsey D. Littrell, Brian T. David, Lee Ryan, Anne M. Herring, Kris L. Kaemingk

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The present study used quantitative volume estimates of the hippocampus based on structural magnetic resonance imaging (MRI) to predict memory performance of individuals with epilepsy of temporal lobe origin (TLE). Twenty individuals with TLE completed standardized neuropsychological tests and a quality of life inventory, and participated in a brain MRI protocol designed to obtain high-resolution images of the hippocampus. The combined volume of the left and right hippocampi was found to be the best predictor of objective verbal memory performance. This finding is consistent with the functional adequacy model of hippocampal function. In contrast, the asymmetry between right and left hippocampal volume was the best predictor of subjective ratings of cognitive functioning, which is consistent with the functional reserve model. The collective and complementary functions of the left and right hippocampi merit further exploration in prospective studies of memory function and TLE.

Original language	English (US)
Pages (from-to)	687-695
Number of pages	9
Journal	Epilepsy and Behavior
Volume	5
Issue number	5
DOIs	https://doi.org/10.1016/j.yebeh.2004.06.006
State	Published - Oct 2004

Keywords

Hippocampus
Magnetic resonance imaging
Memory
Neuropsychology
Quality of life
Temporal lobe epilepsy

ASJC Scopus subject areas

Neurology
Clinical Neurology
Behavioral Neuroscience

Access to Document

10.1016/j.yebeh.2004.06.006

Cite this

@article{8c836b61678b49898a79dcda5ab12b09,

title = "Bilateral hippocampal volume predicts verbal memory function in temporal lobe epilepsy",

abstract = "The present study used quantitative volume estimates of the hippocampus based on structural magnetic resonance imaging (MRI) to predict memory performance of individuals with epilepsy of temporal lobe origin (TLE). Twenty individuals with TLE completed standardized neuropsychological tests and a quality of life inventory, and participated in a brain MRI protocol designed to obtain high-resolution images of the hippocampus. The combined volume of the left and right hippocampi was found to be the best predictor of objective verbal memory performance. This finding is consistent with the functional adequacy model of hippocampal function. In contrast, the asymmetry between right and left hippocampal volume was the best predictor of subjective ratings of cognitive functioning, which is consistent with the functional reserve model. The collective and complementary functions of the left and right hippocampi merit further exploration in prospective studies of memory function and TLE.",

keywords = "Hippocampus, Magnetic resonance imaging, Memory, Neuropsychology, Quality of life, Temporal lobe epilepsy",

author = "Reminger, {Sheryl L.} and Kaszniak, {Alfred W} and Labiner, {David M.} and Littrell, {Lindsey D.} and David, {Brian T.} and Lee Ryan and Herring, {Anne M.} and Kaemingk, {Kris L.}",

note = "Funding Information: This study is based on Dr. Reminger{\textquoteright}s doctoral dissertation submitted to the University of Arizona and was funded through a predoctoral research fellowship from the Epilepsy Foundation of America. Some of these data were presented at the 31st Annual Meeting of the International Neuropsychological Society, Honolulu, HI (February, 2003). The authors thank Deanna Bland for her assistance with patient recruitment, Maryruth Farrell for her assistance with patient contacts, and Marissa Carey, Ph.D., Robyn Kervick, Ph.D., and Claire Venker for their feedback during manuscript preparation.",

year = "2004",

month = oct,

doi = "10.1016/j.yebeh.2004.06.006",

language = "English (US)",

volume = "5",

pages = "687--695",

journal = "Epilepsy and Behavior",

issn = "1525-5050",

publisher = "Academic Press Inc.",

number = "5",

}

TY - JOUR

T1 - Bilateral hippocampal volume predicts verbal memory function in temporal lobe epilepsy

AU - Reminger, Sheryl L.

AU - Kaszniak, Alfred W

AU - Labiner, David M.

AU - Littrell, Lindsey D.

AU - David, Brian T.

AU - Ryan, Lee

AU - Herring, Anne M.

AU - Kaemingk, Kris L.

N1 - Funding Information: This study is based on Dr. Reminger’s doctoral dissertation submitted to the University of Arizona and was funded through a predoctoral research fellowship from the Epilepsy Foundation of America. Some of these data were presented at the 31st Annual Meeting of the International Neuropsychological Society, Honolulu, HI (February, 2003). The authors thank Deanna Bland for her assistance with patient recruitment, Maryruth Farrell for her assistance with patient contacts, and Marissa Carey, Ph.D., Robyn Kervick, Ph.D., and Claire Venker for their feedback during manuscript preparation.

PY - 2004/10

Y1 - 2004/10

N2 - The present study used quantitative volume estimates of the hippocampus based on structural magnetic resonance imaging (MRI) to predict memory performance of individuals with epilepsy of temporal lobe origin (TLE). Twenty individuals with TLE completed standardized neuropsychological tests and a quality of life inventory, and participated in a brain MRI protocol designed to obtain high-resolution images of the hippocampus. The combined volume of the left and right hippocampi was found to be the best predictor of objective verbal memory performance. This finding is consistent with the functional adequacy model of hippocampal function. In contrast, the asymmetry between right and left hippocampal volume was the best predictor of subjective ratings of cognitive functioning, which is consistent with the functional reserve model. The collective and complementary functions of the left and right hippocampi merit further exploration in prospective studies of memory function and TLE.

AB - The present study used quantitative volume estimates of the hippocampus based on structural magnetic resonance imaging (MRI) to predict memory performance of individuals with epilepsy of temporal lobe origin (TLE). Twenty individuals with TLE completed standardized neuropsychological tests and a quality of life inventory, and participated in a brain MRI protocol designed to obtain high-resolution images of the hippocampus. The combined volume of the left and right hippocampi was found to be the best predictor of objective verbal memory performance. This finding is consistent with the functional adequacy model of hippocampal function. In contrast, the asymmetry between right and left hippocampal volume was the best predictor of subjective ratings of cognitive functioning, which is consistent with the functional reserve model. The collective and complementary functions of the left and right hippocampi merit further exploration in prospective studies of memory function and TLE.

KW - Hippocampus

KW - Magnetic resonance imaging

KW - Memory

KW - Neuropsychology

KW - Quality of life

KW - Temporal lobe epilepsy

UR - http://www.scopus.com/inward/record.url?scp=15344348414&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=15344348414&partnerID=8YFLogxK

U2 - 10.1016/j.yebeh.2004.06.006

DO - 10.1016/j.yebeh.2004.06.006

M3 - Article

C2 - 15380120

AN - SCOPUS:15344348414

SN - 1525-5050

VL - 5

SP - 687

EP - 695

JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

IS - 5

ER -

Bilateral hippocampal volume predicts verbal memory function in temporal lobe epilepsy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this