Big roles for small GTPases in the control of directed cell movement

Pascale G. Charest; Richard A. Firtel

doi:10.1042/BJ20061432

Big roles for small GTPases in the control of directed cell movement

Pascale G. Charest, Richard A. Firtel

Research output: Contribution to journal › Review article › peer-review

164 Scopus citations

Abstract

Small GTPases are involved in the control of diverse cellular behaviours, including cellular growth, differentiation and motility. In addition, recent studies have revealed new roles for small GTPases in the regulation of eukaryotic chemotaxis. Efficient chemotaxis results from co-ordinated chemoattractant gradient sensing, cell polarization and cellular motility, and accumulating data suggest that small GTPase signalling plays a central role in each of these processes as well as in signal relay. The present review summarizes these recent findings, which shed light on the molecular mechanisms by which small GTPases control directed cell migration.

Original language	English (US)
Pages (from-to)	377-390
Number of pages	14
Journal	Biochemical Journal
Volume	401
Issue number	2
DOIs	https://doi.org/10.1042/BJ20061432
State	Published - Jan 15 2007
Externally published	Yes

Keywords

Cell polarity
Cellular motility
Directional sensing
Eukaryotic chemotaxis
G-protein

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1042/BJ20061432

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abstract = "Small GTPases are involved in the control of diverse cellular behaviours, including cellular growth, differentiation and motility. In addition, recent studies have revealed new roles for small GTPases in the regulation of eukaryotic chemotaxis. Efficient chemotaxis results from co-ordinated chemoattractant gradient sensing, cell polarization and cellular motility, and accumulating data suggest that small GTPase signalling plays a central role in each of these processes as well as in signal relay. The present review summarizes these recent findings, which shed light on the molecular mechanisms by which small GTPases control directed cell migration.",

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AB - Small GTPases are involved in the control of diverse cellular behaviours, including cellular growth, differentiation and motility. In addition, recent studies have revealed new roles for small GTPases in the regulation of eukaryotic chemotaxis. Efficient chemotaxis results from co-ordinated chemoattractant gradient sensing, cell polarization and cellular motility, and accumulating data suggest that small GTPase signalling plays a central role in each of these processes as well as in signal relay. The present review summarizes these recent findings, which shed light on the molecular mechanisms by which small GTPases control directed cell migration.

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KW - Directional sensing

KW - Eukaryotic chemotaxis

KW - G-protein

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Big roles for small GTPases in the control of directed cell movement

Abstract

Keywords

ASJC Scopus subject areas

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