Abstract
Highly efficient: The title reaction provides biologically interesting chiral trifluoromethyl dihydroquinazolinone frameworks in high yields (up to 97%) and with high enantioselectivities (up to 98% ee), using as low as 1 mol% of catalyst (see scheme). Moreover, anti-HIV drug candidate DPC 083 was efficiently synthesized using the highly enantioselective aza-Henry reaction as a key step.
Original language | English (US) |
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Pages (from-to) | 11773-11776 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 50 |
Issue number | 49 |
DOIs | |
State | Published - Dec 2 2011 |
Externally published | Yes |
Keywords
- alkaloids
- asymmetric synthesis
- aza-Henry reaction
- drug synthesis
- organocatalysis
ASJC Scopus subject areas
- Catalysis
- General Chemistry