Beta radiation in the treatment of in-stent restenosis of an in situ saphenous vein bypass graft: A case report

Kapildeo Lotun; Peter Soukas; Sung Cho; Kevin O'Donnell; André Griben; William T. Irwin; Robert M. Schainfeld

doi:10.1016/j.carrev.2005.02.004

Beta radiation in the treatment of in-stent restenosis of an in situ saphenous vein bypass graft: A case report

Kapildeo Lotun, Peter Soukas, Sung Cho, Kevin O'Donnell, André Griben, William T. Irwin, Robert M. Schainfeld

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Research output: Contribution to journal › Article › peer-review

Abstract

We describe a case of instent restenosis in a femoral-distal saphenous vein bypass graft successfully treated with brachytherapy. A 45-year-old insulin-requiring diabetic woman underwent an in-situ femoral-anterior tibial bypass graft for a non-healing ischemic ulcer. Despite a technically successful percutaneous transluminal angioplasty and endovascular stenting of a retained valve within the threatened graft, the wound failed to heal. At the 1-month follow-up, instent restenosis was documented and successful cutting balloon angioplasty, complemented by adjunctive beta-irradiation was successfully performed. Clinical and hemodynamic success was achieved, with prompt ulcer healing and intermediate-term graft patency maintained on surveillance duplex ultrasound follow-up. We review the literature on radiation therapy in the management of peripheral arterial disease and discuss therapeutic options in the management of restenosis.

Original language	English (US)
Pages (from-to)	75-81
Number of pages	7
Journal	Cardiovascular Revascularization Medicine
Volume	6
Issue number	2
DOIs	https://doi.org/10.1016/j.carrev.2005.02.004
State	Published - 2005

Keywords

Instent restenosis
PTA
Peripheral arterial disease
Vascular irradiation
Venous bypass graft

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.carrev.2005.02.004

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title = "Beta radiation in the treatment of in-stent restenosis of an in situ saphenous vein bypass graft: A case report",

abstract = "We describe a case of instent restenosis in a femoral-distal saphenous vein bypass graft successfully treated with brachytherapy. A 45-year-old insulin-requiring diabetic woman underwent an in-situ femoral-anterior tibial bypass graft for a non-healing ischemic ulcer. Despite a technically successful percutaneous transluminal angioplasty and endovascular stenting of a retained valve within the threatened graft, the wound failed to heal. At the 1-month follow-up, instent restenosis was documented and successful cutting balloon angioplasty, complemented by adjunctive beta-irradiation was successfully performed. Clinical and hemodynamic success was achieved, with prompt ulcer healing and intermediate-term graft patency maintained on surveillance duplex ultrasound follow-up. We review the literature on radiation therapy in the management of peripheral arterial disease and discuss therapeutic options in the management of restenosis.",

keywords = "Instent restenosis, PTA, Peripheral arterial disease, Vascular irradiation, Venous bypass graft",

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T2 - A case report

AU - Lotun, Kapildeo

AU - Soukas, Peter

AU - Cho, Sung

AU - O'Donnell, Kevin

AU - Griben, André

AU - Irwin, William T.

AU - Schainfeld, Robert M.

PY - 2005

Y1 - 2005

N2 - We describe a case of instent restenosis in a femoral-distal saphenous vein bypass graft successfully treated with brachytherapy. A 45-year-old insulin-requiring diabetic woman underwent an in-situ femoral-anterior tibial bypass graft for a non-healing ischemic ulcer. Despite a technically successful percutaneous transluminal angioplasty and endovascular stenting of a retained valve within the threatened graft, the wound failed to heal. At the 1-month follow-up, instent restenosis was documented and successful cutting balloon angioplasty, complemented by adjunctive beta-irradiation was successfully performed. Clinical and hemodynamic success was achieved, with prompt ulcer healing and intermediate-term graft patency maintained on surveillance duplex ultrasound follow-up. We review the literature on radiation therapy in the management of peripheral arterial disease and discuss therapeutic options in the management of restenosis.

AB - We describe a case of instent restenosis in a femoral-distal saphenous vein bypass graft successfully treated with brachytherapy. A 45-year-old insulin-requiring diabetic woman underwent an in-situ femoral-anterior tibial bypass graft for a non-healing ischemic ulcer. Despite a technically successful percutaneous transluminal angioplasty and endovascular stenting of a retained valve within the threatened graft, the wound failed to heal. At the 1-month follow-up, instent restenosis was documented and successful cutting balloon angioplasty, complemented by adjunctive beta-irradiation was successfully performed. Clinical and hemodynamic success was achieved, with prompt ulcer healing and intermediate-term graft patency maintained on surveillance duplex ultrasound follow-up. We review the literature on radiation therapy in the management of peripheral arterial disease and discuss therapeutic options in the management of restenosis.

KW - Instent restenosis

KW - PTA

KW - Peripheral arterial disease

KW - Vascular irradiation

KW - Venous bypass graft

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Beta radiation in the treatment of in-stent restenosis of an in situ saphenous vein bypass graft: A case report

Abstract

Keywords

ASJC Scopus subject areas

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