Benzomorphan alkaloids: Natural peptidomimetics of opioid peptide pharmacophores

Andrzej W. Lipkowski; Aleksandra Misicka; Frank Porreca; Peg Davis; Hank I. Yamamura; Dagmar Stropova; Victor J. Hruby

doi:10.1007/BF00119147

Benzomorphan alkaloids: Natural peptidomimetics of opioid peptide pharmacophores

Andrzej W. Lipkowski, Aleksandra Misicka, Frank Porreca, Peg Davis, Hank I. Yamamura, Dagmar Stropova, Victor J. Hruby

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The synthesis of hybrid analogues of alkaloid nalindol acid and C-terminal fragments of opioid peptides aims to provide the final proof of the proposed topographical relation between opioid peptides and benzomorphan skeleton-containing alkaloids during interaction with receptors. The biological data indicate that the topographical requirements for Tyr¹ and Phe⁴ in opioid peptides are similar for interactions with both δ and κ receptor types.

Original language	English (US)
Pages (from-to)	177-181
Number of pages	5
Journal	Letters in Peptide Science
Volume	2
Issue number	3-4
DOIs	https://doi.org/10.1007/BF00119147
State	Published - Nov 1995

Keywords

Benzomorphan
Computer-assisted intuitional analysis
Dynorphin
Enkephalin
Morphinan
Opioid
Structure-activity relationships

ASJC Scopus subject areas

Biochemistry

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10.1007/BF00119147

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title = "Benzomorphan alkaloids: Natural peptidomimetics of opioid peptide pharmacophores",

abstract = "The synthesis of hybrid analogues of alkaloid nalindol acid and C-terminal fragments of opioid peptides aims to provide the final proof of the proposed topographical relation between opioid peptides and benzomorphan skeleton-containing alkaloids during interaction with receptors. The biological data indicate that the topographical requirements for Tyr1 and Phe4 in opioid peptides are similar for interactions with both δ and κ receptor types.",

keywords = "Benzomorphan, Computer-assisted intuitional analysis, Dynorphin, Enkephalin, Morphinan, Opioid, Structure-activity relationships",

author = "Lipkowski, \{Andrzej W.\} and Aleksandra Misicka and Frank Porreca and Peg Davis and Yamamura, \{Hank I.\} and Dagmar Stropova and Hruby, \{Victor J.\}",

year = "1995",

month = nov,

doi = "10.1007/BF00119147",

language = "English (US)",

volume = "2",

pages = "177--181",

journal = "Letters in Peptide Science",

issn = "0929-5666",

publisher = "Springer Science and Business Media B.V.",

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TY - JOUR

T1 - Benzomorphan alkaloids

T2 - Natural peptidomimetics of opioid peptide pharmacophores

AU - Lipkowski, Andrzej W.

AU - Misicka, Aleksandra

AU - Porreca, Frank

AU - Davis, Peg

AU - Yamamura, Hank I.

AU - Stropova, Dagmar

AU - Hruby, Victor J.

PY - 1995/11

Y1 - 1995/11

N2 - The synthesis of hybrid analogues of alkaloid nalindol acid and C-terminal fragments of opioid peptides aims to provide the final proof of the proposed topographical relation between opioid peptides and benzomorphan skeleton-containing alkaloids during interaction with receptors. The biological data indicate that the topographical requirements for Tyr1 and Phe4 in opioid peptides are similar for interactions with both δ and κ receptor types.

AB - The synthesis of hybrid analogues of alkaloid nalindol acid and C-terminal fragments of opioid peptides aims to provide the final proof of the proposed topographical relation between opioid peptides and benzomorphan skeleton-containing alkaloids during interaction with receptors. The biological data indicate that the topographical requirements for Tyr1 and Phe4 in opioid peptides are similar for interactions with both δ and κ receptor types.

KW - Benzomorphan

KW - Computer-assisted intuitional analysis

KW - Dynorphin

KW - Enkephalin

KW - Morphinan

KW - Opioid

KW - Structure-activity relationships

UR - https://www.scopus.com/pages/publications/0008679016

UR - https://www.scopus.com/inward/citedby.url?scp=0008679016&partnerID=8YFLogxK

U2 - 10.1007/BF00119147

DO - 10.1007/BF00119147

M3 - Article

AN - SCOPUS:0008679016

SN - 0929-5666

VL - 2

SP - 177

EP - 181

JO - Letters in Peptide Science

JF - Letters in Peptide Science

IS - 3-4

ER -

Benzomorphan alkaloids: Natural peptidomimetics of opioid peptide pharmacophores

Abstract

Keywords

ASJC Scopus subject areas

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