Benzofuran based PDE4 inhibitors

D. G. McGarry; J. R. Regan; F. A. Volz; C. Hulme; K. J. Moriarty; S. W. Djuric; J. E. Souness; B. E. Miller; J. J. Travis; D. M. Sweeney

doi:10.1016/S0968-0896(99)00038-3

Benzofuran based PDE4 inhibitors

D. G. McGarry, J. R. Regan, F. A. Volz, C. Hulme, K. J. Moriarty, S. W. Djuric, J. E. Souness, B. E. Miller, J. J. Travis, D. M. Sweeney

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Replacement of the 3,4-dialkoxyphenyl substructure common to a number of PDE4 inhibitors with a 2-alkyl-7-methoxybenzofuran unit is described. This substitution can result in either enhancement or substantial reductions in PDE4 inhibitory activity depending on the system to which it is applied. An in vitro SAR study of a potent series of 4-(2-heteroaryl-ethyl)-benzofurans 26 is also presented. Copyright (C) 1999 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	1131-1139
Number of pages	9
Journal	Bioorganic and Medicinal Chemistry
Volume	7
Issue number	6
DOIs	https://doi.org/10.1016/S0968-0896(99)00038-3
State	Published - Jun 1999
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0968-0896(99)00038-3

Cite this

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title = "Benzofuran based PDE4 inhibitors",

abstract = "Replacement of the 3,4-dialkoxyphenyl substructure common to a number of PDE4 inhibitors with a 2-alkyl-7-methoxybenzofuran unit is described. This substitution can result in either enhancement or substantial reductions in PDE4 inhibitory activity depending on the system to which it is applied. An in vitro SAR study of a potent series of 4-(2-heteroaryl-ethyl)-benzofurans 26 is also presented. Copyright (C) 1999 Elsevier Science Ltd.",

author = "McGarry, {D. G.} and Regan, {J. R.} and Volz, {F. A.} and C. Hulme and Moriarty, {K. J.} and Djuric, {S. W.} and Souness, {J. E.} and Miller, {B. E.} and Travis, {J. J.} and Sweeney, {D. M.}",

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AU - McGarry, D. G.

AU - Regan, J. R.

AU - Volz, F. A.

AU - Hulme, C.

AU - Moriarty, K. J.

AU - Djuric, S. W.

AU - Souness, J. E.

AU - Miller, B. E.

AU - Travis, J. J.

AU - Sweeney, D. M.

PY - 1999/6

Y1 - 1999/6

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Benzofuran based PDE4 inhibitors

Abstract

ASJC Scopus subject areas

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