Benchmark analysis: Shopping with proper confidence

Walter W. Piegorsch, R. Webster West

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


We discuss the issue of using benchmark doses for quantifying (excess) risk associated with exposure to environmental hazards. The paradigm of low-dose risk estimation in dose-response modeling is used as the primary application scenario. Emphasis is placed on making simultaneous inferences on benchmark doses when data are in the form of proportions, although the concepts translate easily to other forms of outcome data.

Original languageEnglish (US)
Pages (from-to)913-920
Number of pages8
JournalRisk Analysis
Issue number4
StatePublished - Aug 2005


  • BMD
  • BMDL
  • Benchmark dose
  • Low-dose extrapolation
  • Post hoc comparisons
  • Quantitative risk assessment
  • Simultaneous inferences

ASJC Scopus subject areas

  • Safety, Risk, Reliability and Quality
  • Physiology (medical)


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