TY - JOUR
T1 - Beclomethasone dipropionate crystallized from HFA-134a and ethanol
AU - Harris, Julie A.
AU - Carducci, Michael D.
AU - Myrdal, Paul B.
PY - 2003/11
Y1 - 2003/11
N2 - Beclomethasone dipropionate (BDP) is a long-acting inhaled corticosteroid, used for the treatment of asthma, and as an inhalation therapy with HFA-134a. The sample studied by X-ray crystallography was grown in a mixture of the aerosol propellant HFA-134a, C2H2F4, and 200-proof ethanol. The formula of the crystalline material is C 28H37ClO7·2C2H 6O·C2H2F4. In the crystal structure, disordered solvent occupies a channel which is perpendicular to the BDP molecules. The latter are are stacked together by hydrogen bonding.
AB - Beclomethasone dipropionate (BDP) is a long-acting inhaled corticosteroid, used for the treatment of asthma, and as an inhalation therapy with HFA-134a. The sample studied by X-ray crystallography was grown in a mixture of the aerosol propellant HFA-134a, C2H2F4, and 200-proof ethanol. The formula of the crystalline material is C 28H37ClO7·2C2H 6O·C2H2F4. In the crystal structure, disordered solvent occupies a channel which is perpendicular to the BDP molecules. The latter are are stacked together by hydrogen bonding.
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U2 - 10.1107/S1600536803021196
DO - 10.1107/S1600536803021196
M3 - Article
AN - SCOPUS:18444403530
VL - 59
SP - o1631-o1633
JO - Acta Crystallographica Section E: Structure Reports Online
JF - Acta Crystallographica Section E: Structure Reports Online
SN - 1600-5368
IS - 11
ER -