Beclomethasone dipropionate crystallized from HFA-134a and ethanol

Julie A. Harris; Michael D. Carducci; Paul B. Myrdal

doi:10.1107/S1600536803021196

Beclomethasone dipropionate crystallized from HFA-134a and ethanol

Julie A. Harris, Michael D. Carducci, Paul B. Myrdal

Pharmacy Practice and Science

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10 Scopus citations

Abstract

Beclomethasone dipropionate (BDP) is a long-acting inhaled corticosteroid, used for the treatment of asthma, and as an inhalation therapy with HFA-134a. The sample studied by X-ray crystallography was grown in a mixture of the aerosol propellant HFA-134a, C₂H₂F₄, and 200-proof ethanol. The formula of the crystalline material is C ₂₈H₃₇ClO₇·2C₂H ₆O·C₂H₂F₄. In the crystal structure, disordered solvent occupies a channel which is perpendicular to the BDP molecules. The latter are are stacked together by hydrogen bonding.

Original language	English (US)
Pages (from-to)	o1631-o1633
Journal	Acta Crystallographica Section E: Structure Reports Online
Volume	59
Issue number	11
DOIs	https://doi.org/10.1107/S1600536803021196
State	Published - Nov 2003

ASJC Scopus subject areas

General Chemistry
General Materials Science
Condensed Matter Physics

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10.1107/S1600536803021196

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title = "Beclomethasone dipropionate crystallized from HFA-134a and ethanol",

abstract = "Beclomethasone dipropionate (BDP) is a long-acting inhaled corticosteroid, used for the treatment of asthma, and as an inhalation therapy with HFA-134a. The sample studied by X-ray crystallography was grown in a mixture of the aerosol propellant HFA-134a, C2H2F4, and 200-proof ethanol. The formula of the crystalline material is C 28H37ClO7·2C2H 6O·C2H2F4. In the crystal structure, disordered solvent occupies a channel which is perpendicular to the BDP molecules. The latter are are stacked together by hydrogen bonding.",

author = "Harris, {Julie A.} and Carducci, {Michael D.} and Myrdal, {Paul B.}",

year = "2003",

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T1 - Beclomethasone dipropionate crystallized from HFA-134a and ethanol

AU - Harris, Julie A.

AU - Carducci, Michael D.

AU - Myrdal, Paul B.

PY - 2003/11

Y1 - 2003/11

N2 - Beclomethasone dipropionate (BDP) is a long-acting inhaled corticosteroid, used for the treatment of asthma, and as an inhalation therapy with HFA-134a. The sample studied by X-ray crystallography was grown in a mixture of the aerosol propellant HFA-134a, C2H2F4, and 200-proof ethanol. The formula of the crystalline material is C 28H37ClO7·2C2H 6O·C2H2F4. In the crystal structure, disordered solvent occupies a channel which is perpendicular to the BDP molecules. The latter are are stacked together by hydrogen bonding.

AB - Beclomethasone dipropionate (BDP) is a long-acting inhaled corticosteroid, used for the treatment of asthma, and as an inhalation therapy with HFA-134a. The sample studied by X-ray crystallography was grown in a mixture of the aerosol propellant HFA-134a, C2H2F4, and 200-proof ethanol. The formula of the crystalline material is C 28H37ClO7·2C2H 6O·C2H2F4. In the crystal structure, disordered solvent occupies a channel which is perpendicular to the BDP molecules. The latter are are stacked together by hydrogen bonding.

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Beclomethasone dipropionate crystallized from HFA-134a and ethanol

Abstract

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CCDC 226945: Experimental Crystal Structure Determination

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Beclomethasone dipropionate crystallized from HFA-134a and ethanol

Abstract

ASJC Scopus subject areas

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Datasets

CCDC 226945: Experimental Crystal Structure Determination

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