TY - JOUR
T1 - Basic and Clinical Concepts Related to Vitamin D Metabolism and Action
AU - Haussler, Mark R.
AU - Mccain, Toni A.
PY - 1977/11/3
Y1 - 1977/11/3
N2 - (First of Two Parts) A NOVEL sterol hormone that is undoubtedly a major physiologic regulator of mineral metabolism in man, 1α,25-dihydroxyvitamin D (1,25(OH)2D), is produced from vitamin D in response to situations of calcium and phosphorus need, with the final enzymatic reaction occurring in the kidney. A complex and elegant biochemical mechanism is thought to function at the pivotal kidney site to modulate the biosynthesis of this most active form of vitamin D. In concert with other calcitropic principles, such as parathyroid hormone (PTH) and calcitonin, the l,25-(OH)2D hormone mediates calcium and phosphorus metabolism at target.
AB - (First of Two Parts) A NOVEL sterol hormone that is undoubtedly a major physiologic regulator of mineral metabolism in man, 1α,25-dihydroxyvitamin D (1,25(OH)2D), is produced from vitamin D in response to situations of calcium and phosphorus need, with the final enzymatic reaction occurring in the kidney. A complex and elegant biochemical mechanism is thought to function at the pivotal kidney site to modulate the biosynthesis of this most active form of vitamin D. In concert with other calcitropic principles, such as parathyroid hormone (PTH) and calcitonin, the l,25-(OH)2D hormone mediates calcium and phosphorus metabolism at target.
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U2 - 10.1056/NEJM197711032971804
DO - 10.1056/NEJM197711032971804
M3 - Review article
C2 - 333287
AN - SCOPUS:0017700602
SN - 0028-4793
VL - 297
SP - 974
EP - 983
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 18
ER -