Basic and Clinical Concepts Related to Vitamin D Metabolism and Action

Mark R. Haussler, Toni A. Mccain

Research output: Contribution to journalReview articlepeer-review

177 Scopus citations


(Second of Two Parts) Assays for Vitamin D Metabolites The basic advances in our understanding of the metabolism and mechanism of action of vitamin D not only are important in physiology and nutrition but have been successfully applied to the study of the pathophysiology of a myriad of metabolic bone disorders. Initially, assay procedures were developed to measure vitamin D metabolites. Competitive protein binding is the most widely used method for the assay of vitamin D metabolites, and various selective binding proteins, such as plasma carriers and intracellular receptors, have been employed. These measurements have led to increased comprehension of.

Original languageEnglish (US)
Pages (from-to)1041-1050
Number of pages10
JournalNew England Journal of Medicine
Issue number19
StatePublished - Nov 10 1977

ASJC Scopus subject areas

  • General Medicine


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