Band 1p36 abnormalities and t(1;17) in ovarian carcinoma

Floyd H. Thompson; Raymond Taetle; Jeffrey M. Trent; Yun Liu; Kathy Massey-Brown; Katherine M. Scott; Ronald S. Weinstein; Julia C. Emerson; David S. Alberts; Mark A. Nelson

doi:10.1016/S0165-4608(96)00307-X

Band 1p36 abnormalities and t(1;17) in ovarian carcinoma

Floyd H. Thompson, Raymond Taetle, Jeffrey M. Trent, Yun Liu, Kathy Massey-Brown, Katherine M. Scott, Ronald S. Weinstein, Julia C. Emerson, David S. Alberts, Mark A. Nelson

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

In a series of 128 karyotyped ovarian carcinomas, 42% of cases with chromosome 1 clonal structural abnormalities had breaks at band 1p36 (usually involving translocations of unknown material). Fluorescent in situ hybridization (FISH) studies using combinations of 1 centromere and 1p36.3- specific probes (16 cases) or 1 centromeric and 17 whole-chromosome paint probes (11 cases with 1p+) revealed a trend toward deletion of 1pter relative to 1 centromere (63%); intratumor heterogeneity; and the origin of 1p+ in 3/11 cases (27%) from chromosome 17[t(1;17)(p36;?)]. The frequency of this specific breakpoint and its involvement in recurrent translocations suggest that these regions are loci for genes important in the pathogenesis of a subset of sporadic ovarian carcinomas.

Original language	English (US)
Pages (from-to)	106-110
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	96
Issue number	2
DOIs	https://doi.org/10.1016/S0165-4608(96)00307-X
State	Published - Jul 15 1997

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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title = "Band 1p36 abnormalities and t(1;17) in ovarian carcinoma",

abstract = "In a series of 128 karyotyped ovarian carcinomas, 42% of cases with chromosome 1 clonal structural abnormalities had breaks at band 1p36 (usually involving translocations of unknown material). Fluorescent in situ hybridization (FISH) studies using combinations of 1 centromere and 1p36.3- specific probes (16 cases) or 1 centromeric and 17 whole-chromosome paint probes (11 cases with 1p+) revealed a trend toward deletion of 1pter relative to 1 centromere (63%); intratumor heterogeneity; and the origin of 1p+ in 3/11 cases (27%) from chromosome 17[t(1;17)(p36;?)]. The frequency of this specific breakpoint and its involvement in recurrent translocations suggest that these regions are loci for genes important in the pathogenesis of a subset of sporadic ovarian carcinomas.",

author = "Thompson, {Floyd H.} and Raymond Taetle and Trent, {Jeffrey M.} and Yun Liu and Kathy Massey-Brown and Scott, {Katherine M.} and Weinstein, {Ronald S.} and Emerson, {Julia C.} and Alberts, {David S.} and Nelson, {Mark A.}",

note = "Funding Information: This article is dedicated to the memory of Mr. Floyd Thompson. We acknowledge the technical assistance of Lee Wisner. This work was supported by R29CA70145-01 (M. A. N.), the Friends of the Arizona Cancer Center (Phoenix chapter), and in part by NCI grants CA-41183 and CA-23074. ",

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doi = "10.1016/S0165-4608(96)00307-X",

language = "English (US)",

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AU - Thompson, Floyd H.

AU - Taetle, Raymond

AU - Trent, Jeffrey M.

AU - Liu, Yun

AU - Massey-Brown, Kathy

AU - Scott, Katherine M.

AU - Weinstein, Ronald S.

AU - Emerson, Julia C.

AU - Alberts, David S.

AU - Nelson, Mark A.

N1 - Funding Information: This article is dedicated to the memory of Mr. Floyd Thompson. We acknowledge the technical assistance of Lee Wisner. This work was supported by R29CA70145-01 (M. A. N.), the Friends of the Arizona Cancer Center (Phoenix chapter), and in part by NCI grants CA-41183 and CA-23074.

PY - 1997/7/15

Y1 - 1997/7/15

N2 - In a series of 128 karyotyped ovarian carcinomas, 42% of cases with chromosome 1 clonal structural abnormalities had breaks at band 1p36 (usually involving translocations of unknown material). Fluorescent in situ hybridization (FISH) studies using combinations of 1 centromere and 1p36.3- specific probes (16 cases) or 1 centromeric and 17 whole-chromosome paint probes (11 cases with 1p+) revealed a trend toward deletion of 1pter relative to 1 centromere (63%); intratumor heterogeneity; and the origin of 1p+ in 3/11 cases (27%) from chromosome 17[t(1;17)(p36;?)]. The frequency of this specific breakpoint and its involvement in recurrent translocations suggest that these regions are loci for genes important in the pathogenesis of a subset of sporadic ovarian carcinomas.

AB - In a series of 128 karyotyped ovarian carcinomas, 42% of cases with chromosome 1 clonal structural abnormalities had breaks at band 1p36 (usually involving translocations of unknown material). Fluorescent in situ hybridization (FISH) studies using combinations of 1 centromere and 1p36.3- specific probes (16 cases) or 1 centromeric and 17 whole-chromosome paint probes (11 cases with 1p+) revealed a trend toward deletion of 1pter relative to 1 centromere (63%); intratumor heterogeneity; and the origin of 1p+ in 3/11 cases (27%) from chromosome 17[t(1;17)(p36;?)]. The frequency of this specific breakpoint and its involvement in recurrent translocations suggest that these regions are loci for genes important in the pathogenesis of a subset of sporadic ovarian carcinomas.

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Band 1p36 abnormalities and t(1;17) in ovarian carcinoma

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