Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication

John M. Ryniawec, Gregory C. Rogers

Research output: Contribution to journalArticlepeer-review

Abstract

Polo-like kinase 4 (Plk4) is the master regulator of centriole assembly. Several evolutionarily conserved mechanisms strictly regulate Plk4 abundance and activity to ensure cells maintain a proper number of centrioles. In this issue of Genes & Development, Phan et al. (pp. 718–736) add to this growing list by describing a new mechanism of control that restricts Plk4 translation through competitive ribosome binding at upstream open reading frames (uORFs) in the mature Plk4 mRNA. Fascinatingly, this mechanism is especially critical in the development of primordial germ cells in mice that are transcriptionally hyperactive and thus exquisitely sensitive to Plk4 mRNA regulation.

Original languageEnglish (US)
Pages (from-to)647-649
Number of pages3
JournalGenes and Development
Volume36
Issue number11-12
DOIs
StatePublished - Jun 1 2022

Keywords

  • Polo-like kinase 4
  • centriole amplification
  • primordial germ cell
  • translational regulation
  • upstream open reading frame

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Fingerprint

Dive into the research topics of 'Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication'. Together they form a unique fingerprint.

Cite this