Abstract
Opioid studies are an important area of modern medicinal chemistry research. In this study we have provided innovative considerations to some long-standing problems in opioid studies, specifically the opioid pharmacophore and the potential binding modes of opioid ligands. Based on a new peptide backbone-alignment concept that we have developed along with this study, we discuss a wide variety of opioid ligands with respect to their structure - activity relationships. (Figure presented).
Original language | English (US) |
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Pages (from-to) | 1151-1164 |
Number of pages | 14 |
Journal | Journal of Chemical Information and Modeling |
Volume | 51 |
Issue number | 5 |
DOIs | |
State | Published - May 23 2011 |
ASJC Scopus subject areas
- General Chemistry
- General Chemical Engineering
- Computer Science Applications
- Library and Information Sciences