B cells and osteoblast and osteoclast development

Mark C. Horowitz, Alfred L.M. Bothwell, David G.T. Hesslein, David L. Pflugh, David G. Schatz

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


The molecules that regulate bone cell development, particularly at the early stages of development, are only partially known. Data are accumulating that indicate a complex relationship exists between B cells and bone cell differentiation. Although the exact nature of this relationship is still evolving, it takes at least two forms. First, factors that regulate B-cell growth and development have striking effects on osteoclast and osteoblast lineage cells. Similarly, factors that regulate bone cell development influence B-cell maturation. Second, a series of transcription factors required for B-cell differentiation have been identified, and these factors function in a developmentally ordered circuit. These transcription factors have unpredicted, pronounced, and non-overlapping effects on osteoblast and/or osteoclast development. These data indicate that at least a regulatory relationship exists between B lymphopoiesis, osteoclastogenesis, and osteoblastogenesis.

Original languageEnglish (US)
Pages (from-to)141-153
Number of pages13
JournalImmunological Reviews
StatePublished - Dec 2005
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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