B-cell lymphomas with discordance between pathological features and clinical behavior

Laurence de Leval, Christiane Copie-Bergman, Andreas Rosenwald, Lisa Rimsza, Stefania Pittaluga, Bettina Bisig, Stefan Dirnhofer, Fabio Facchetti, Stefano Pileri, Falko Fend, Andrew Wotherspoon

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


B-cell lymphomas encompass a large number of disease entities clinically ranging from indolent to aggressive. The defining pathological features usually predict clinical course, with small and large B-cell lymphomas correlating to low-grade vs high-grade features, but discordant situations may be encountered. Two sessions of the workshop of the XVIII meeting of the European Association for Haematopathology (EAHP) held in Basel in 2016 addressed this topic. One session illustrated various facets of “aggressiveness” in indolent lymphomas, either peculiar clinical manifestations, cytological variants, or unusual genetic features, as well as several examples of progression or transformation to a more aggressive disease. Another session exemplified large B-cell lymphomas with unexpected indolent behavior including cases arising in well-defined body compartments or in sanctuary sites. This paper describes the features of the cases presented in both groups, highlights the most salient points of discussion raised by the submitters and the panel, and summarizes current knowledge and recommendations relevant to diagnostic pathology practice.

Original languageEnglish (US)
Pages (from-to)439-451
Number of pages13
JournalVirchows Archiv
Issue number4
StatePublished - Oct 1 2017


  • B-cell lymphomas
  • Clinical behavior
  • Cytology
  • Discordance
  • Genetics
  • Pathological features
  • Progression
  • Transformation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology


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