Abstract
The role of autophagy in ageing regulation has been suggested based on studies in C. elegans, in which knockdown of the expression of bec-1 (ortholog of the yeast and mammalian autophagy genes ATG6/VPS30 and beclin 1, respectively) shortens lifespan of the daf-2(e1370) mutant C. elegans. However, Beclin1/ATG6 is also known to be involved in other cellular functions in addition to autophagy. In the current study, we knocked down two other autophagy genes, atg-7 and atg-12, in C. elegans using RNAi. We showed that RNAi shortened the lifespan of both wild type and daf-2 mutant C. elegans, providing strong support for a role of autophagy in ageing regulation.
Original language | English (US) |
---|---|
Pages (from-to) | 93-95 |
Number of pages | 3 |
Journal | Autophagy |
Volume | 3 |
Issue number | 2 |
DOIs | |
State | Published - 2007 |
Externally published | Yes |
Keywords
- Ageing
- Autophagy
- Lifespan
- atg-12
- atg-7
- bec-1
- daf-2
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology