Autophagy in amyotrophic lateral sclerosis

Jozsef Gal, Haining Zhu

Research output: Chapter in Book/Report/Conference proceedingChapter


Amyotrophic lateral sclerosis (ALS, Lou Gehrig’s disease) is a neurodegenerative disease that primarily affects motor neurons. Mutations in multiple genes have been found to cause the familial forms of ALS. Research has been primarily focused on the familial ALS cases using animal and cellular models. The etiology of the disease is still not fully understood despite the intensive research. Increasing amount of evidence suggests that the perturbation or insufficiency of cellular protein turnover, especially autophagy, plays an important role in ALS pathogenesis. In this chapter, we review the involvement of impaired protein turnover by autophagy in ALS and discuss the role of familial ALS mutations in causing such autophagic impairment.

Original languageEnglish (US)
Title of host publicationAutophagy of the Nervous System
Subtitle of host publicationCellular Self-Digestion in Neurons and Neurological Diseases
PublisherWorld Scientific Publishing Co.
Number of pages31
ISBN (Electronic)9789814350457
ISBN (Print)9789814350440
StatePublished - Jan 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Neuroscience(all)


Dive into the research topics of 'Autophagy in amyotrophic lateral sclerosis'. Together they form a unique fingerprint.

Cite this