Automated registration of sequential breath-hold dynamic contrast-enhanced MR images: A comparison of three techniques

Sivaramakrishnan Rajaraman, Jeffrey J. Rodriguez, Christian Graff, Maria I. Altbach, Tomislav Dragovich, Claude B. Sirlin, Ronald L. Korn, Natarajan Raghunand

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is increasingly in use as an investigational biomarker of response in cancer clinical studies. Proper registration of images acquired at different time points is essential for deriving diagnostic information from quantitative pharmacokinetic analysis of these data. Motion artifacts in the presence of time-varying intensity due to contrast enhancement make this registration problem challenging. DCE-MRI of chest and abdominal lesions is typically performed during sequential breath-holds, which introduces misregistration due to inconsistent diaphragm positions and also places constraints on temporal resolution vis-à-vis free-breathing. In this work, we have employed a computer-generated DCE-MRI phantom to compare the performance of two published methods, Progressive Principal Component Registration and Pharmacokinetic Model-Driven Registration, with Sequential Elastic Registration (SER) to register adjacent time-sample images using a published general-purpose elastic registration algorithm. In all three methods, a 3D rigid-body registration scheme with a mutual information similarity measure was used as a preprocessing step. The DCE-MRI phantom images were mathematically deformed to simulate misregistration, which was corrected using the three schemes. All three schemes were comparably successful in registering large regions of interest (ROIs) such as muscle, liver, and spleen. SER was superior in retaining tumor volume and shape, and in registering smaller but important ROIs such as tumor core and tumor rim. The performance of SER on clinical DCE-MRI data sets is also presented.

Original languageEnglish (US)
Pages (from-to)668-682
Number of pages15
JournalMagnetic Resonance Imaging
Issue number5
StatePublished - Jun 2011


  • Dynamic
  • Elastic registration
  • Gadolinium
  • MRI
  • Mutual information
  • Non-rigid registration
  • Tracer kinetics

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging


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