Attachment & detachment of prostate cancer cells in a microfluidic system

L. S.L. Cheung; X. J. Zheng; A. Stopa; J. Schroeder; R. L. Hemark; J. C. Baygents; R. Guzman; Y. Zohar

Attachment & detachment of prostate cancer cells in a microfluidic system

L. S.L. Cheung, X. J. Zheng, A. Stopa, J. Schroeder, R. L. Hemark, J. C. Baygents, R. Guzman, Y. Zohar

Research output: Contribution to conference › Paper › peer-review

Abstract

Cadherins make up a family of cell adhesion molecules, and one cadherin subtype only interacts with its counter receptor. Cancer cells typically down-regulate Ecadherin and up-regulate N-cadherin. Hence, a microchannel-based system is developed, with immobilized anti-N-cadherin antibodies, for highly specific capture of prostate cancer cells under both static (no-flow) and dynamic (flow) conditions. The maximum number of detached cells, after capture, is found to depend not only on the flow-induced shear stress but also on the rate of change of the applied shear stress.

Original language	English (US)
Pages	1159-1161
Number of pages	3
State	Published - 2008
Event	12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States Duration: Oct 12 2008 → Oct 16 2008

Other

Other	12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
Country/Territory	United States
City	San Diego, CA
Period	10/12/08 → 10/16/08

Keywords

Cell attachment/detachment
Circulating tumor cell
Microdevices

ASJC Scopus subject areas

Chemical Engineering (miscellaneous)
Bioengineering

Cite this

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title = "Attachment & detachment of prostate cancer cells in a microfluidic system",

abstract = "Cadherins make up a family of cell adhesion molecules, and one cadherin subtype only interacts with its counter receptor. Cancer cells typically down-regulate Ecadherin and up-regulate N-cadherin. Hence, a microchannel-based system is developed, with immobilized anti-N-cadherin antibodies, for highly specific capture of prostate cancer cells under both static (no-flow) and dynamic (flow) conditions. The maximum number of detached cells, after capture, is found to depend not only on the flow-induced shear stress but also on the rate of change of the applied shear stress.",

keywords = "Cell attachment/detachment, Circulating tumor cell, Microdevices",

author = "Cheung, {L. S.L.} and Zheng, {X. J.} and A. Stopa and J. Schroeder and Hemark, {R. L.} and Baygents, {J. C.} and R. Guzman and Y. Zohar",

year = "2008",

language = "English (US)",

pages = "1159--1161",

note = "12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 ; Conference date: 12-10-2008 Through 16-10-2008",

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TY - CONF

T1 - Attachment & detachment of prostate cancer cells in a microfluidic system

AU - Cheung, L. S.L.

AU - Zheng, X. J.

AU - Stopa, A.

AU - Schroeder, J.

AU - Hemark, R. L.

AU - Baygents, J. C.

AU - Guzman, R.

AU - Zohar, Y.

PY - 2008

Y1 - 2008

N2 - Cadherins make up a family of cell adhesion molecules, and one cadherin subtype only interacts with its counter receptor. Cancer cells typically down-regulate Ecadherin and up-regulate N-cadherin. Hence, a microchannel-based system is developed, with immobilized anti-N-cadherin antibodies, for highly specific capture of prostate cancer cells under both static (no-flow) and dynamic (flow) conditions. The maximum number of detached cells, after capture, is found to depend not only on the flow-induced shear stress but also on the rate of change of the applied shear stress.

AB - Cadherins make up a family of cell adhesion molecules, and one cadherin subtype only interacts with its counter receptor. Cancer cells typically down-regulate Ecadherin and up-regulate N-cadherin. Hence, a microchannel-based system is developed, with immobilized anti-N-cadherin antibodies, for highly specific capture of prostate cancer cells under both static (no-flow) and dynamic (flow) conditions. The maximum number of detached cells, after capture, is found to depend not only on the flow-induced shear stress but also on the rate of change of the applied shear stress.

KW - Cell attachment/detachment

KW - Circulating tumor cell

KW - Microdevices

UR - http://www.scopus.com/inward/record.url?scp=84902471901&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902471901&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:84902471901

SP - 1159

EP - 1161

T2 - 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008

Y2 - 12 October 2008 through 16 October 2008

ER -

Attachment & detachment of prostate cancer cells in a microfluidic system

Abstract

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Keywords

ASJC Scopus subject areas

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