ATPases and lens ion balance

Christopher A. Paterson, Nicholas A. Delamere

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


In the lens, different cells appear to be specialized such that some have a high capacity for energy-dependent ion transport while others do not. This short review describes the distribution of functional Na,K-ATPase activity and Ca-ATPase activity in the lens. Movement of ions in the extracellular space between lens fibers, a topic studied by David Maurice 25 years ago, is discussed together with cell-to-cell movement of ions which is facilitated by extensive coupling in the lens cell mass. The expression of different Na,K-ATPase and Ca-ATPase isoforms in lens epithelium and fiber cells is considered along with mechanisms that potentially regulate the activity of these transport proteins.

Original languageEnglish (US)
Pages (from-to)699-703
Number of pages5
JournalExperimental eye research
Issue number3
StatePublished - Mar 2004


  • Ca-ATPase
  • Lens
  • Na,K-ATPase
  • PMCA

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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